亮氨酸和D-3-羟基丁酸作为发育中大鼠脊髓和肝脏的脂质前体。
Leucine and D-3-hydroxybutyrate as lipid precursors in developing rat spinal cord and liver.
作者信息
Ramsey R B
出版信息
Biochem J. 1976 Aug 15;158(2):501-4. doi: 10.1042/bj1580501.
Abstract
By using a labelled ketone body, D-3-hydroxy[3-14C]butyrate, or a ketone-body precursor, L-[4,5-3H]leucine, preferential labelling of spinal-cord cholesterol was demonstrated. In contrast, the phospholipid fraction was more heavily labelled in the liver. In both tissues phosphatidylcholine was the major labelled complex lipid. Incorporation ob both substrates into total lipid, on a tissue-weight basis, was appreciably greater for spinal cord.
摘要
通过使用一种标记的酮体，D-3-羟基[3-¹⁴C]丁酸，或一种酮体前体，L-[4,5-³H]亮氨酸，证实了脊髓胆固醇的优先标记。相比之下，肝脏中的磷脂部分标记更重。在这两种组织中，磷脂酰胆碱都是主要的标记复合脂质。以组织重量为基础，两种底物掺入总脂质的量在脊髓中明显更高。
相似文献
1
Leucine and D-3-hydroxybutyrate as lipid precursors in developing rat spinal cord and liver.亮氨酸和D-3-羟基丁酸作为发育中大鼠脊髓和肝脏的脂质前体。
Biochem J. 1976 Aug 15;158(2):501-4. doi: 10.1042/bj1580501.
2
In vivo utilization of D(-)-3-hydroxybutyrate by chick brain and spinal cord.
Neurochem Res. 1990 May;15(5):529-33. doi: 10.1007/BF00966212.
3
Binding sites for [3H]gamma-hydroxybutyrate on cultured neurones of rat cerebellum and spinal cord.[3H]γ-羟基丁酸在大鼠小脑和脊髓培养神经元上的结合位点
Neurosci Lett. 1983 Dec 2;42(2):145-8. doi: 10.1016/0304-3940(83)90397-x.
4
Preferential labeling of brain cholesterol by (3-14C)D(-)-3-hydroxybutyrate.(3-14C)D(-)-3-羟基丁酸对脑胆固醇的优先标记
Lipids. 1973 Nov;8(11):649-51. doi: 10.1007/BF02533150.
5
Acetoacetate is a cholesterogenic precursor for myelinating rat brain and spinal cord. Incorporation of label from [3-14C]acetoacetate, [14C]glucose and 3H2O.乙酰乙酸是大鼠脑和脊髓髓鞘形成过程中的胆固醇生成前体。[3-¹⁴C]乙酰乙酸、[¹⁴C]葡萄糖和³H₂O中标记物的掺入。
Biochim Biophys Acta. 1984 Jul 6;794(2):350-2. doi: 10.1016/0005-2760(84)90167-x.
6
Effect of DL-3-hydroxybutyrate infusions on leucine and glucose kinetics in burned rats receiving TPN.DL-3-羟基丁酸输注对接受全胃肠外营养的烧伤大鼠亮氨酸和葡萄糖动力学的影响。
J Nutr. 1986 Jan;116(1):149-56. doi: 10.1093/jn/116.1.149.
7
8
Effects of oleic acid on the biosynthesis of lipoprotein apoproteins and distribution into the very-low-density lipoprotein by the isolated perfused rat liver.油酸对离体灌注大鼠肝脏脂蛋白载脂蛋白生物合成及向极低密度脂蛋白分布的影响。
Biochem J. 1988 May 1;251(3):809-16. doi: 10.1042/bj2510809.
9
The effects of mild congenital methylmercury intoxication on the metabolism of 3-hydroxybutyrate and glucose in the brains of suckling rats.
Neurotoxicology. 1985 Spring;6(1):55-61.
10
The role of phosphatidylcholine biosynthesis in the secretion of lipoproteins from hepatocytes.磷脂酰胆碱生物合成在肝细胞脂蛋白分泌中的作用。
Can J Biochem Cell Biol. 1985 Aug;63(8):870-81. doi: 10.1139/o85-108.
引用本文的文献
1
Phosphatidylserine decarboxylase 1 (Psd1) promotes mitochondrial fusion by regulating the biophysical properties of the mitochondrial membrane and alternative topogenesis of mitochondrial genome maintenance protein 1 (Mgm1).磷酸丝氨酸脱羧酶 1（Psd1）通过调节线粒体膜的物理特性和线粒体基因组维持蛋白 1（Mgm1）的替代拓扑发生，促进线粒体融合。
J Biol Chem. 2012 Nov 23;287(48):40131-9. doi: 10.1074/jbc.M112.399428. Epub 2012 Oct 8.
2
NADP-dependent dehydrogenases in rat liver parenchyma. III. The description of a liponeogenic area on the basis of histochemically demonstrated enzyme activities and the neutral fat content during fasting and refeeding.大鼠肝实质中的NADP依赖性脱氢酶。III. 根据组织化学显示的酶活性及禁食和再喂食期间的中性脂肪含量对一个脂肪生成区域的描述。
Histochemistry. 1981;72(4):579-615. doi: 10.1007/BF00493277.
3
Age-related quantitative changes in enzyme activities of rat brain.大鼠脑酶活性的年龄相关定量变化。
Neurochem Res. 1981 Feb;6(2):127-36. doi: 10.1007/BF00964829.
4
The contribution of the cholesterol biosynthetic pathway to intermediary metabolism and cell function.胆固醇生物合成途径对中间代谢和细胞功能的贡献。
Biochem J. 1981 Oct 1;199(1):1-7. doi: 10.1042/bj1990001.
5
Isolation of alveolar type II cells by centrifugal elutriation.通过离心淘析法分离肺泡II型细胞。
In Vitro. 1979 Sep;15(9):673-84. doi: 10.1007/BF02618246.
本文引用的文献
1
BRAIN CHOLESTEROL. VI. THE EFFECT OF HEREDITARY DYSTROPHIA MUSCULARIS ON (C14)LEUCINE AND (2-3H)ACETATE INCORPORATION.
Tex Rep Biol Med. 1964;22:134-41.
2
Brain cholesterol: biosynthesis with selected precursors in vivo.脑胆固醇：体内利用特定前体物质的生物合成过程。
J Neurochem. 1961 Aug;7:298-304. doi: 10.1111/j.1471-4159.1961.tb13516.x.
3
Metabolism of myelin: the persistence of (4-14C) cholesterol in the mammalian central nervous system.髓磷脂的代谢：（4-¹⁴C）胆固醇在哺乳动物中枢神经系统中的持久性。
Lancet. 1959 Mar 28;1(7074):658-60. doi: 10.1016/s0140-6736(59)92403-1.
4
A simple method for the isolation and purification of total lipides from animal tissues.一种从动物组织中分离和纯化总脂质的简单方法。
J Biol Chem. 1957 May;226(1):497-509.
5
Studies on the biosynthesis of cholesterol. III. Purification of C14-cholesterol from perfusions of livers and other organs.胆固醇生物合成的研究。III. 从肝脏和其他器官灌注液中纯化C14-胆固醇。
Arch Biochem Biophys. 1952 Oct;40(2):334-41. doi: 10.1016/0003-9861(52)90119-7.
6
Leucine and mevalonate as precursors of serum cholesterol in man.亮氨酸和甲羟戊酸作为人体血清胆固醇的前体。
Acta Med Scand. 1968 Sep;184(3):159-64. doi: 10.1111/j.0954-6820.1968.tb02437.x.
7
Comparison of leucine with mevalonate and acetate as a precursor of tissue and serum cholesterol in the rat.亮氨酸与甲羟戊酸及乙酸作为大鼠组织和血清胆固醇前体的比较。
Ann Med Exp Biol Fenn. 1971;49(1):20-8.
8
The incorporation of cholesterol into the nervous system of the newly hatched chick.
Acta Physiol Scand. 1970 Sep;80(1):45-9. doi: 10.1111/j.1748-1716.1970.tb04768.x.
9
Ketone-body utilization by adult and suckling rat brain in vivo.成年和哺乳大鼠大脑在体内对酮体的利用
Biochem J. 1971 Mar;122(1):13-8. doi: 10.1042/bj1220013.
10
Activities of enzymes of ketone-body utilization in brain and other tissues of suckling rats.乳鼠大脑及其他组织中酮体利用酶的活性
Biochem J. 1971 Jan;121(1):49-53. doi: 10.1042/bj1210049.
Zotero 插件