亮氨酸和D-3-羟基丁酸作为发育中大鼠脊髓和肝脏的脂质前体。
Leucine and D-3-hydroxybutyrate as lipid precursors in developing rat spinal cord and liver.
作者信息
Ramsey R B
出版信息
Biochem J. 1976 Aug 15;158(2):501-4. doi: 10.1042/bj1580501.
Abstract
By using a labelled ketone body, D-3-hydroxy[3-14C]butyrate, or a ketone-body precursor, L-[4,5-3H]leucine, preferential labelling of spinal-cord cholesterol was demonstrated. In contrast, the phospholipid fraction was more heavily labelled in the liver. In both tissues phosphatidylcholine was the major labelled complex lipid. Incorporation ob both substrates into total lipid, on a tissue-weight basis, was appreciably greater for spinal cord.
摘要
通过使用一种标记的酮体，D-3-羟基[3-¹⁴C]丁酸，或一种酮体前体，L-[4,5-³H]亮氨酸，证实了脊髓胆固醇的优先标记。相比之下，肝脏中的磷脂部分标记更重。在这两种组织中，磷脂酰胆碱都是主要的标记复合脂质。以组织重量为基础，两种底物掺入总脂质的量在脊髓中明显更高。
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