Sheĭbak V M
Laboratory of Medico-Biological Problems of Narcology, Grodno Medical Institute, Belarus.
Eksp Klin Farmakol. 1998 Sep-Oct;61(5):59-61.
The effect of polyamine on the total content of free amino acids and the structure of the amino acid fund in blood plasma and hepatic tissue was studied in rats with chronic alcoholic intoxication. Rapid utilization of exogenic introduced amino acids and a normalizing effect of the drug on the structure of the amino acid fund were demonstrated. The high concentration of aromatic amino acids in the drug may be among the causes of the increased content of this fraction of amino acids in the tissues studied after administration of the drug.
研究了多胺对慢性酒精中毒大鼠血浆和肝组织中游离氨基酸总含量及氨基酸库结构的影响。结果表明,外源性引入的氨基酸被快速利用,且该药物对氨基酸库结构具有归一化作用。药物中高浓度的芳香族氨基酸可能是给药后所研究组织中该部分氨基酸含量增加的原因之一。