Inhibition of prothrombin synthesis and epoxidation of vitamin K1 by anticoagulants in vitro. - Suppr | 超能文献

Inhibition of prothrombin synthesis and epoxidation of vitamin K1 by anticoagulants in vitro.

作者信息

Bell R G, Stark P

出版信息

Biochem Biophys Res Commun. 1976 Sep 20;72(2):619-25. doi: 10.1016/s0006-291x(76)80085-x.

DOI:10.1016/s0006-291x(76)80085-x

Abstract

摘要

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Vitamin K reduction precedes epoxidation and prothrombin synthesis.

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Mechanism of action of anticoagulants: correlation between the inhibition of prothrombin synthesis and the regeneration of vitamin K1 from vitamin K1 epoxide.抗凝剂的作用机制：凝血酶原合成抑制与维生素K1环氧化物向维生素K1再生之间的相关性。

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引用本文的文献

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NAD(P)H dehydrogenase and its role in the vitamin K (2-methyl-3-phytyl-1,4-naphthaquinone)-dependent carboxylation reaction.NAD(P)H脱氢酶及其在维生素K（2-甲基-3-植基-1,4-萘醌）依赖性羧化反应中的作用。

Biochem J. 1978 Jan 1;169(1):95-101. doi: 10.1042/bj1690095.

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Vitamin K-dependent carboxylase: evidence for a hydroperoxide intermediate in the reaction.维生素K依赖性羧化酶：反应中氢过氧化物中间体的证据。

Proc Natl Acad Sci U S A. 1978 Nov;75(11):5413-6. doi: 10.1073/pnas.75.11.5413.