8,9-Dihydro-8,9-dihydroxybenz(a)anthracene 10,11-oxide: a new type of polycyclic aromatic hydrocarbon metabolite.

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作者信息

Booth J, Sims P

出版信息

FEBS Lett. 1974 Oct 1;47(1):30-3. doi: 10.1016/0014-5793(74)80419-9.

DOI:10.1016/0014-5793(74)80419-9

PMID:4154213

Abstract

摘要

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8,9-Dihydro-8,9-dihydroxybenz(a)anthracene 10,11-oxide: a new type of polycyclic aromatic hydrocarbon metabolite.

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Polycyclic hydrocarbon epoxides: the involvement of 8,9-dihydro-8,9-dihydroxybenz (a) anthracene 10,11-oxide in reactions with the DNA of benz (a) anthracene-treated hamster embryo cells.

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Epoxy derivatives of aromatic polycyclic hydrocarbons. The preparation and metabolism of epoxides related to 7,12-dimethylbenz(a)anthracene.芳香多环烃的环氧衍生物。与7,12-二甲基苯并(a)蒽相关的环氧化物的制备与代谢。

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Epoxy derivatives of aromatic polycyclic hydrocarbons. The preparation of benz( )anthracene 8,9-oxide and 10,11-dihydrobenz( )anthracene 8,9-oxide and their metabolism by rat liver preparations.芳香多环烃的环氧衍生物。苯并（）蒽8,9 - 氧化物和10,11 - 二氢苯并（）蒽8,9 - 氧化物的制备及其在大鼠肝脏制剂中的代谢。

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Isolation by high pressure liquid chromatography and characterization of benzo(a)pyrene-4'5-epoxide as a metobolite of benzoapyrene.通过高压液相色谱法分离并鉴定苯并(a)芘-4'5-环氧化物作为苯并芘的一种代谢产物。

Arch Biochem Biophys. 1975 May;168(1):322-6. doi: 10.1016/0003-9861(75)90256-8.

Epoxy derivatives of aromatic polycyclic hydrocarbons. The synthesis of dibenz[a,c]anthracene 10,11-oxide and its metabolism by rat liver preparations.芳香多环烃的环氧衍生物。二苯并[a,c]蒽10,11-氧化物的合成及其在大鼠肝脏制剂中的代谢。

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Glutathione conjugates as metabolites of benz[a]anthracene.

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Epoxides as reactive intermediates in aromatic hydrocarbon metabolism.环氧化物作为芳烃代谢中的反应性中间体。

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The formation of "K-region" epoxides as hepatic microsomal metabolites of 7-methylbenz(a)anthracene and 7,12-dimethylbenz(a)anthracene and their 7-hydroxymethyl derivatives.

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Leucoplakia of the oral cavity, smoking and arylhydrocarbon-hydroxylase inducibility.口腔白斑、吸烟与芳烃羟化酶诱导性

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Epoxides--is there a human health problem?环氧化合物——存在人类健康问题吗？

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Metabolic conversion of dibenz[a,h]anthracene (+/-)trans-1,2-dihydrodiol and chrysene (+/-)trans-3,4-dihydrodiol to vicinal dihydrodiol epoxides.二苯并[a,h]蒽（±）反式-1,2-二氢二醇和屈（±）反式-3,4-二氢二醇向邻位二氢二醇环氧化物的代谢转化。

Proc Natl Acad Sci U S A. 1981 Jul;78(7):4270-3. doi: 10.1073/pnas.78.7.4270.

Metabolism of benzo[a]pyrene: conversion of (+/-)-trans-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene to highly mutagenic 7,8-diol-9,10-epoxides.苯并[a]芘的代谢：（±）-反式-7,8-二羟基-7,8-二氢苯并[a]芘向高致突变性的7,8-二羟基-9,10-环氧化物的转化。

Proc Natl Acad Sci U S A. 1976 Oct;73(10):3381-5. doi: 10.1073/pnas.73.10.3381.

Tumour-initiating activities on mouse skin of dihydrodiols derived from benzo[a]pyrene.苯并[a]芘衍生的二氢二醇对小鼠皮肤的肿瘤起始活性。

Br J Cancer. 1976 Nov;34(5):523-32. doi: 10.1038/bjc.1976.207.

Tumorigenicity of five dihydrodiols of benz(a)anthracene on mouse skin: exceptional activity of benz(a)anthracene 3,4-dihydrodiol.苯并(a)蒽的五种二氢二醇对小鼠皮肤的致瘤性：苯并(a)蒽3,4 -二氢二醇的异常活性。

Proc Natl Acad Sci U S A. 1977 Aug;74(8):3176-9. doi: 10.1073/pnas.74.8.3176.

Comparison of mutagenesis and malignant transformation by dihydrodiols from benz[a]anthracene and 7,12-dimethylbenz[a]anthracene.苯并[a]蒽和7,12-二甲基苯并[a]蒽的二氢二醇的诱变作用与恶性转化的比较。

Br J Cancer. 1979 May;39(5):540-7. doi: 10.1038/bjc.1979.99.

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