Berton F, Vogel E, Belzung C
LEPCO, UFR Sciences et Techniques, Tours, France.
Physiol Behav. 1998 Nov 15;65(2):247-54. doi: 10.1016/s0031-9384(98)00126-7.
The effectiveness of predator odours as repellents was assessed, and the behavioral antipredatory responses were characterized. Mice had free access to an unfamiliar runway containing different olfactory stimuli: modelling clay, or feces of a cat subjected either to a vegetarian or a carnivorous diet. The first experiment revealed various indices of a spontaneous behavioral pattern that included exploratory activity, different kinds of emotionality, and a range of active or passive defensive reactions until the appearance of absence of risk assessment strictly related to presence or absence of anxiety. These reactions differ with larger responses to feces resulting from a carnivorous as opposed to vegetarian diets. In the second experiment, chlordiazepoxide (0, 2.5, 5, or 7.5 mg/kg) had a dose-related anxiolytic effect on exploration in mice of both vegetarian and carnivorous groups but could not totally reverse the strong anxiogenic effect of carnivorous stimulus on defensive mechanisms. These differences are related to the nature of the mammalian cues. This paradigm may be a fear-motivated model of animal anxiety.
评估了捕食者气味作为驱避剂的有效性，并对行为性反捕食反应进行了表征。小鼠可以自由进入一条不熟悉的跑道，跑道上含有不同的嗅觉刺激物：橡皮泥，或食用素食或肉食的猫的粪便。第一个实验揭示了一种自发行为模式的各种指标，包括探索活动、不同类型的情绪以及一系列主动或被动防御反应，直到出现与焦虑的存在与否严格相关的无风险评估。这些反应有所不同，对肉食性饮食产生的粪便的反应比对素食性饮食产生的粪便的反应更大。在第二个实验中，氯氮卓（0、2.5、5或7.5毫克/千克）对素食组和肉食组小鼠的探索行为都有剂量相关的抗焦虑作用，但不能完全逆转肉食性刺激对防御机制的强烈致焦虑作用。这些差异与哺乳动物线索的性质有关。这种范式可能是一种动物焦虑的恐惧驱动模型。
