Williams C M, Rogers P J, Kirkham T C
Department of Psychology, University of Reading, Whiteknights, UK.
Physiol Behav. 1998 Nov 15;65(2):343-6. doi: 10.1016/s0031-9384(98)00170-x.
Using a pre-feed paradigm, the effects of orally-administered delta9-tetrahydrocannabinol (THC) on low baseline levels of nocturnal feeding were assessed. Following 2-h access to a palatable wet mash diet at dark onset, adult male Lister hooded rats (Charles River) were treated with either sesame seed oil vehicle or delta9- tetrahydrocannabinol (0.063, 0.12, 0.25, 0.5, 1.0, or 2.0 mg/kg). One hour later, rats were allowed ad libitum access to standard chow, and intakes were monitored over the subsequent 24 h. Doses of 0.5, 1.0, and 2.0 mg/kg produced substantial hyperphagia during the first hour of testing. Subsequently, rats compensated for their overconsumption so that 24-h intakes were similar in all conditions. The data confirm anecdotal reports of the orexigenic actions of exogenous cannabinoids and suggest a critical role for endogenous cannabinoid systems in the regulation of appetite.
采用预喂食范式，评估了口服δ9-四氢大麻酚（THC）对夜间低基线摄食水平的影响。在黑暗开始时给予成年雄性利斯特戴帽大鼠（查尔斯河实验室）2小时美味湿软食饮食后，分别用芝麻油载体或δ9-四氢大麻酚（0.063、0.12、0.25、0.5、1.0或2.0mg/kg）进行处理。1小时后，让大鼠自由摄取标准饲料，并在随后的24小时内监测摄入量。0.5、1.0和2.0mg/kg的剂量在测试的第一个小时内产生了显著的食欲亢进。随后，大鼠对过量摄食进行了补偿，因此在所有条件下24小时摄入量相似。这些数据证实了关于外源性大麻素促食欲作用的传闻报道，并表明内源性大麻素系统在食欲调节中起关键作用。
