慢性炎性脱髓鞘性多发性神经病与黑色素瘤中的分子模拟
Molecular mimicry in chronic inflammatory demyelinating polyneuropathy and melanoma.
作者信息
Weiss M D, Luciano C A, Semino-Mora C, Dalakas M C, Quarles R H
机构信息
Laboratory of Molecular and Cellular Neurobiology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.
出版信息
Neurology. 1998 Dec;51(6):1738-41. doi: 10.1212/wnl.51.6.1738.
Polyclonal immunoglobulin M antibodies to the monosialoganglioside GM2, sulfoglucuronyl glycolipids, and sulfatide were detected by thin-layer chromatography and enzyme-linked immunosorbent assay in the serum of a patient with melanoma and chronic inflammatory demyelinating polyneuropathy. Both the patient's serum and polyclonal antibodies against GM2 reacted strongly with a biopsy of melanomatous tissue from the patient, suggesting a process of molecular mimicry.
通过薄层色谱法和酶联免疫吸附测定法，在一名患有黑色素瘤和慢性炎症性脱髓鞘性多发性神经病患者的血清中检测到了针对单唾液酸神经节苷脂GM2、硫酸葡萄糖醛酸糖脂和硫苷脂的多克隆免疫球蛋白M抗体。患者血清和抗GM2多克隆抗体均与该患者黑色素瘤组织活检强烈反应，提示分子模拟过程。
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