Sae-Lim V, Wang C Y, Trope M
Department of Endodontics, School of Dentistry, University of North Carolina at Chapel Hill 27599-7450, USA.
Endod Dent Traumatol. 1998 Oct;14(5):216-20. doi: 10.1111/j.1600-9657.1998.tb00842.x.
The use of systemic penicillin after an avulsion injury has been recommended as a way to decrease the occurrence of resorption complications. Our previous study has shown systemic tetracycline to possess anti-resorptive properties independent of potential anti-bacterial actions. The purpose of this study was to compare histologically the effectiveness of tetracycline and amoxicillin in limiting inflammatory root resorption (IR) secondary to pulpal infection, in replanted dogs' teeth. Thirty root canals in five dogs were infected with plaque. The roots were extracted, the lingual mid-roots were shaved with a fissure bur ensuring cemental damage and immediately replanted. Dogs were given either tetracycline hydrochloride or amoxicillin, administered orally, on the day of extraction and replantation and for the following 6 days. The control group was teeth in these animals treated in the same manner but where no antibiotics were given. After approximately 6 months, the dogs were sacrificed and the teeth prepared for histologic evaluation. The shaved root surface was identified in cross-sections and eight equidistant points along the cut root surface were evaluated for healing (H) or IR in eight sections per tooth. For the tetracycline group, H averaged 67.22% and IR 32.78%, which was not statistically different from the amoxicillin group with H averaging 56.88% and IR 43.12%. The tetracycline group was superior to the control group with H = 27.86% and IR = 72.14%. Since tetracycline has been shown to have anti-resorptive properties in addition to the antibacterial properties demonstrated here, it could be considered as an alternative to amoxicillin after avulsion injuries.
在撕脱伤后使用全身性青霉素被推荐为一种减少吸收并发症发生的方法。我们之前的研究表明，全身性四环素具有抗吸收特性，与潜在的抗菌作用无关。本研究的目的是从组织学角度比较四环素和阿莫西林在限制再植犬牙继发于牙髓感染的炎性牙根吸收（IR）方面的有效性。对五只犬的30个根管进行菌斑感染。拔除牙根，用裂钻刮除舌侧牙根中部，确保牙骨质受损，然后立即再植。在拔牙和再植当天及随后6天，给犬口服盐酸四环素或阿莫西林。对照组为这些动物中以相同方式处理但未给予抗生素的牙齿。大约6个月后，处死犬并制备牙齿进行组织学评估。在横切面上识别刮除的牙根表面，每颗牙齿在八个切片中沿着切割的牙根表面的八个等距点评估愈合（H）或IR情况。四环素组H平均为67.22%，IR为32.78%，与阿莫西林组相比无统计学差异，阿莫西林组H平均为56.88%，IR为43.12%。四环素组优于对照组，对照组H = 27.86%，IR = 72.14%。由于四环素除了在此显示的抗菌特性外还具有抗吸收特性，因此在撕脱伤后可被视为阿莫西林的替代品。
