Attenuation of hyperinsulinemia in polycystic ovary syndrome: what are the options?

作者信息

Ehrmann D A

机构信息

Department of Medicine, University of Chicago, IL 60637, USA.

出版信息

J Endocrinol Invest. 1998 Oct;21(9):632-5. doi: 10.1007/BF03350790.

DOI:10.1007/BF03350790

PMID:9856419

Abstract

摘要

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本文引用的文献

Metformin therapy improves the menstrual pattern with minimal endocrine and metabolic effects in women with polycystic ovary syndrome.

Fertil Steril. 1998 Apr;69(4):691-6. doi: 10.1016/s0015-0282(98)00011-9.

Therapeutic effects of metformin on insulin resistance and hyperandrogenism in polycystic ovary syndrome.

Eur J Endocrinol. 1998 Mar;138(3):269-74. doi: 10.1530/eje.0.1380269.

Relation of functional ovarian hyperandrogenism to non-insulin dependent diabetes mellitus.

Baillieres Clin Obstet Gynaecol. 1997 Jun;11(2):335-47. doi: 10.1016/s0950-3552(97)80040-5.

Efficacy and metabolic effects of metformin and troglitazone in type II diabetes mellitus.

N Engl J Med. 1998 Mar 26;338(13):867-72. doi: 10.1056/NEJM199803263381303.

Insulin resistance and the polycystic ovary syndrome: mechanism and implications for pathogenesis.

Endocr Rev. 1997 Dec;18(6):774-800. doi: 10.1210/edrv.18.6.0318.

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Hum Reprod. 1997 Oct;12 Suppl 1:82-7. doi: 10.1093/humrep/12.suppl_1.82.

Lean women with polycystic ovary syndrome respond to insulin reduction with decreases in ovarian P450c17 alpha activity and serum androgens.

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Menstrual cyclicity after metformin therapy in polycystic ovary syndrome.

Obstet Gynecol. 1997 Sep;90(3):392-5. doi: 10.1016/s0029-7844(97)00296-2.

Troglitazone improves defects in insulin action, insulin secretion, ovarian steroidogenesis, and fibrinolysis in women with polycystic ovary syndrome.

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Metformin therapy is associated with a decrease in plasma plasminogen activator inhibitor-1, lipoprotein(a), and immunoreactive insulin levels in patients with the polycystic ovary syndrome.

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