Siapas A G, Wilson M A
Center for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge 02139, USA.
Neuron. 1998 Nov;21(5):1123-8. doi: 10.1016/s0896-6273(00)80629-7.
Sleep is characterized by a structured combination of neuronal oscillations. In the hippocampus, slow-wave sleep (SWS) is marked by high-frequency network oscillations (approximately 200 Hz "ripples"), whereas neocortical SWS activity is organized into low-frequency delta (1-4 Hz) and spindle (7-14 Hz) oscillations. While these types of hippocampal and cortical oscillations have been studied extensively in isolation, the relationships between them remain unknown. Here, we demonstrate the existence of temporal correlations between hippocampal ripples and cortical spindles that are also reflected in the correlated activity of single neurons within these brain structures. Spindle-ripple episodes may thus constitute an important mechanism of cortico-hippocampal communication during sleep. This coactivation of hippocampal and neocortical pathways may be important for the process of memory consolidation, during which memories are gradually translated from short-term hippocampal to longer-term neocortical stores.
睡眠的特征是神经元振荡的结构化组合。在海马体中，慢波睡眠（SWS）以高频网络振荡（约200赫兹的“涟漪”）为特征，而新皮质慢波睡眠活动则组织成低频δ波（1 - 4赫兹）和纺锤波（7 - 14赫兹）振荡。虽然这些类型的海马体和皮质振荡已被广泛地单独研究，但它们之间的关系仍然未知。在这里，我们证明了海马体涟漪和皮质纺锤波之间存在时间相关性，这也反映在这些脑结构内单个神经元的相关活动中。因此，纺锤波 - 涟漪事件可能构成睡眠期间皮质 - 海马体通信的重要机制。海马体和新皮质通路的这种共同激活可能对记忆巩固过程很重要，在此过程中，记忆逐渐从短期的海马体存储转化为长期的新皮质存储。
