大鼠在七氟醚与异氟醚麻醉期间的局部脑血流量、局部脑葡萄糖利用率及血流-代谢耦合

Local cerebral blood flow, local cerebral glucose utilization, and flow-metabolism coupling during sevoflurane versus isoflurane anesthesia in rats.

作者信息

Lenz C, Rebel A, van Ackern K, Kuschinsky W, Waschke K F

机构信息

Department of Anesthesiology, Faculty of Clinical Medicine, University of Heidelberg, Mannheim, Germany.

出版信息

Anesthesiology. 1998 Dec;89(6):1480-8. doi: 10.1097/00000542-199812000-00026.

DOI:10.1097/00000542-199812000-00026

PMID:9856723

Abstract

BACKGROUND

Compared to isoflurane, knowledge of local cerebral glucose utilization (LCGU) and local cerebral blood flow (LCBF) during sevoflurane anesthesia is limited.

METHODS

LCGU, LCBF, and their overall means were measured in Sprague-Dawley rats (8 groups, n=6 each) during sevoflurane and isoflurane anesthesia, 1 and 2 MAC, and in conscious control animals (2 groups, n=6 each) using the autoradiographic 2-[14C]deoxy-D-glucose and 4-iodo-N-methyl-[14C]antipyrine methods.

RESULTS

During anesthesia, mean cerebral glucose utilization was decreased: control, 56+/-5 micronmol x 100 g(-1) x min(-1); 1 MAC isoflurane, 32+/-4 micromol x 100 g(-1) x min(-1) (-43%); 1 MAC sevoflurane, 37+/-5 micromol x 100 g(-1) x min(-1) (-34%); 2 MAC isoflurane, 23+/-3 micromol x 100 g(-1) x min(-1) (-58%); 2 MAC sevoflurane, 23+/-5 micromol x 100 g(-1) x min(-1) (-59%). Local analysis showed a reduction in LCGU in the majority of the 40 brain regions analyzed. Mean cerebral blood flow was increased as follows: control 93+/-8 ml x 100 g(-1) x min(-1); 1 MAC isofurane, 119+/-19 ml x 100 g(-1) x min(-1) (+28%); 1 MAC sevoflurane, 104+/-15 ml x 100 g(-1) x min(-1) (+12%); 2 MAC isoflurane, 149+/-17 ml x 100 g(-1) x min(-1) (+60%); 2 MAC sevoflurane, 118+/-21 ml x 100 g(-1) min(-1) (+27%). LCBF was increased in most brain structures investigated. Correlation coefficients obtained for the relationship between LCGU and LCBF were as follows: control 0.93; 1 MAC isoflurane, 0.89; 2 MAC isoflurane, 0.71; 1 MAC sevoflurane, 0.83; 2 MAC sevoflurane, 0.59).

CONCLUSION

Mean and local cerebral blood flows were lower during sevoflurane than during isoflurane anesthesia. This difference cannot be explained by differing changes in glucose utilization because glucose utilization was decreased to the same extent in both groups.

摘要

背景

与异氟烷相比，七氟烷麻醉期间局部脑葡萄糖利用（LCGU）和局部脑血流（LCBF）的相关知识有限。

方法

采用放射自显影2-[14C]脱氧-D-葡萄糖和4-碘-N-甲基-[14C]安替比林方法，在七氟烷和异氟烷麻醉（1和2 MAC）期间以及清醒对照动物（2组，每组n = 6）中，对Sprague-Dawley大鼠（8组，每组n = 6）的LCGU、LCBF及其总体均值进行测量。

结果

麻醉期间，平均脑葡萄糖利用降低：对照组，56±5微摩尔×100克-1×分钟-1；1 MAC异氟烷，32±4微摩尔×100克-1×分钟-1（-43%）；1 MAC七氟烷，37±5微摩尔×100克-1×分钟-1（-34%）；2 MAC异氟烷，23±3微摩尔×100克-1×分钟-1（-58%）；2 MAC七氟烷，23±5微摩尔×100克-1×分钟-1（-59%）。局部分析显示，在所分析的40个脑区中的大多数区域，LCGU均降低。平均脑血流增加情况如下：对照组93±8毫升×100克-1×分钟-1；1 MAC异氟烷，119±19毫升×100克-1×分钟-1（+28%）；1 MAC七氟烷，104±15毫升×100克-1×分钟-1（+12%）；2 MAC异氟烷，149±17毫升×100克-1×分钟-1（+60%）；2 MAC七氟烷，118±21毫升×100克-1分钟-1（+27%）。在所研究的大多数脑结构中，LCBF均增加。LCGU与LCBF之间关系的相关系数如下：对照组0.93；1 MAC异氟烷，0.89；2 MAC异氟烷，0.71；1 MAC七氟烷，0.83；2 MAC七氟烷，0.59。