Bessou-Touya S, Picardo M, Maresca V, Surlève-Bazeille J E, Pain C, Taïeb A
Dermatology Laboratory, University Victor Ségalen Bordeaux II, France.
J Invest Dermatol. 1998 Dec;111(6):1103-8. doi: 10.1046/j.1523-1747.1998.00405.x.
Chimeric epidermal reconstructs made with Negroid melanocytes and Caucasoid keratinocytes (or vice versa) were studied before and after UVB irradiation to understand the respective roles of these cells in tanning and photoprotection, especially lipoperoxidation and enzymatic defences against free radicals. Using this approach, we have confirmed overall the theory of the epidermal melanin unit. We have also shown that melanocytes of poorly tanning Caucasoids, which have a comparatively higher content of unsaturated fatty acids in their cell membrane, are more prone to the peroxidative effects of UV light, and that keratinocytes participate in photoprotection via phototype-dependent antioxidant enzyme activities, especially for catalase.
用人种学上的黑素细胞和高加索人种的角质形成细胞（或反之亦然）构建的嵌合表皮重建物在紫外线B（UVB）照射前后进行了研究，以了解这些细胞在晒黑和光保护中的各自作用，特别是脂质过氧化作用和针对自由基的酶防御作用。通过这种方法，我们总体上证实了表皮黑素单位的理论。我们还表明，不易晒黑的高加索人种的黑素细胞，其细胞膜中不饱和脂肪酸含量相对较高，更容易受到紫外线的过氧化作用影响，并且角质形成细胞通过光型依赖性抗氧化酶活性参与光保护，尤其是过氧化氢酶。
