实验性哮喘中独立于白细胞介素-4的白细胞介素-13需求
Requirement for IL-13 independently of IL-4 in experimental asthma.
作者信息
Grünig G, Warnock M, Wakil A E, Venkayya R, Brombacher F, Rennick D M, Sheppard D, Mohrs M, Donaldson D D, Locksley R M, Corry D B
机构信息
Department of Medicine, San Francisco General Hospital, University of California San Francisco, San Francisco, CA 94143, USA.
出版信息
Science. 1998 Dec 18;282(5397):2261-3. doi: 10.1126/science.282.5397.2261.
Abstract
The pathogenesis of asthma reflects, in part, the activity of T cell cytokines. Murine models support participation of interleukin-4 (IL-4) and the IL-4 receptor in asthma. Selective neutralization of IL-13, a cytokine related to IL-4 that also binds to the alpha chain of the IL-4 receptor, ameliorated the asthma phenotype, including airway hyperresponsiveness, eosinophil recruitment, and mucus overproduction. Administration of either IL-13 or IL-4 conferred an asthma-like phenotype to nonimmunized T cell-deficient mice by an IL-4 receptor alpha chain-dependent pathway. This pathway may underlie the genetic associations of asthma with both the human 5q31 locus and the IL-4 receptor.
摘要
哮喘的发病机制部分反映了T细胞细胞因子的活性。小鼠模型支持白细胞介素-4（IL-4）和IL-4受体参与哮喘发病。IL-13是一种与IL-4相关且也与IL-4受体α链结合的细胞因子，对其进行选择性中和可改善哮喘表型，包括气道高反应性、嗜酸性粒细胞募集和黏液过度产生。给予IL-13或IL-4均可通过IL-4受体α链依赖性途径使未免疫的T细胞缺陷小鼠呈现哮喘样表型。该途径可能是哮喘与人类5q31基因座和IL-4受体之间遗传关联的基础。
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1
2
3
Requirements for allergen-induced airway hyperreactivity in T and B cell-deficient mice.T细胞和B细胞缺陷小鼠中变应原诱导的气道高反应性的条件
Mol Med. 1998 May;4(5):344-55.
4
Differences between IL-4R alpha-deficient and IL-4-deficient mice reveal a role for IL-13 in the regulation of Th2 responses.白细胞介素-4受体α缺陷型小鼠与白细胞介素-4缺陷型小鼠之间的差异揭示了白细胞介素-13在调节Th2反应中的作用。
Curr Biol. 1998 May 21;8(11):669-72. doi: 10.1016/s0960-9822(98)70256-8.
5
Ile50Val variant of IL4R alpha upregulates IgE synthesis and associates with atopic asthma.白细胞介素4受体α亚基的Ile50Val变体上调免疫球蛋白E的合成并与特应性哮喘相关。
Nat Genet. 1998 Jun;19(2):119-20. doi: 10.1038/472.
6
A critical role for IL-13 in resistance to intestinal nematode infection.白细胞介素-13在抵抗肠道线虫感染中起关键作用。
J Immunol. 1998 Apr 1;160(7):3453-61.
7
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Immunity. 1998 Feb;8(2):255-64. doi: 10.1016/s1074-7613(00)80477-x.
8
The association of atopy with a gain-of-function mutation in the alpha subunit of the interleukin-4 receptor.特应性与白细胞介素-4受体α亚基功能获得性突变之间的关联。
N Engl J Med. 1997 Dec 11;337(24):1720-5. doi: 10.1056/NEJM199712113372403.
9
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10
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