Foley J E, Lapointe J M, Koblik P, Poland A, Pedersen N C
Center for Companion Animal Health, School of Veterinary Medicine, University of California, Davis 95616, USA.
J Vet Intern Med. 1998 Nov-Dec;12(6):415-23. doi: 10.1111/j.1939-1676.1998.tb02144.x.
Feline infectious peritonitis (FIP) is a fatal Arthus-type immune response of cats to infection with FIP virus, a mutant of the ubiquitous feline enteric coronavirus (FECV). The disease may occur systemically or in any single organ system, and primary neurologic disease is a common subset of such manifestations. We examined 16 domestic cats with clinical neurologic FIP and 8 control cats with nonneurologic FIP, with the intention of identifying the ante- and postmortem diagnostic tests that most contribute to accurate diagnosis. Of the 16 cats with neurologic FIP, 15 were less than 2 years of age and all 16 originated from large multiple-cat households. The most useful antemortem indicators of disease were positive anti-coronavirus IgG titer in cerebrospinal fluid, high serum total protein concentration, and findings on magnetic resonance imaging suggesting periventricular contrast enhancement, ventricular dilatation, and hydrocephalus. Postmortem diagnosis was facilitated by FIP monoclonal antibody staining of affected tissue and coronavirus-specific polymerase chain reaction. Most cats with neurologic and ocular forms of FIP had patchy, focal lesions, suggesting that recently developed technologies described in this report may be useful for evaluation of cats with suspected FIP.
猫传染性腹膜炎（FIP）是猫对感染FIP病毒的一种致命的阿瑟斯型免疫反应，FIP病毒是普遍存在的猫肠道冠状病毒（FECV）的一种突变体。该疾病可能全身性发生或出现在任何单一器官系统中，原发性神经疾病是此类表现的常见亚型。我们检查了16只患有临床神经性FIP的家猫和8只患有非神经性FIP的对照猫，旨在确定对准确诊断最有帮助的生前和死后诊断测试。在16只患有神经性FIP的猫中，15只年龄小于2岁，且所有16只均来自大型多猫家庭。最有用的生前疾病指标是脑脊液中抗冠状病毒IgG滴度呈阳性、血清总蛋白浓度高，以及磁共振成像结果提示脑室周围强化、脑室扩张和脑积水。通过对受影响组织进行FIP单克隆抗体染色和冠状病毒特异性聚合酶链反应，有助于死后诊断。大多数患有神经性和眼部形式FIP的猫有斑片状、局灶性病变，这表明本报告中描述的最新技术可能有助于评估疑似FIP的猫。
