Greene C E, McDermott M, Jameson P H, Atkins C L, Marks A M
Department of Small Animal Medicine, College of Veterinary Medicine, University of Georgia, Athens 30602, USA.
J Clin Microbiol. 1996 Jul;34(7):1682-5. doi: 10.1128/JCM.34.7.1682-1685.1996.
Bartonella henselae infection was established in eight cats of various ages by experimental inoculation. All cats remained persistently bacteremic until they were treated 4 to 7 weeks after primary inoculation. Antibody titers increased and peaked between 4 and 12 weeks for all cats. Treatment with doxycycline for 1 week was effective in suppressing bacteremia in all cats but was effective in clearing infection from only four cats. Amoxicillin, given subsequently, was effective in clearing the infection from three of the remaining cats. One kitten that remained bacteremic was treated unsuccessfully with enrofloxacin, and its bacteremia was finally cleared when it was treated with a clavulanate-amoxicillin combination. After the bacteremia was cleared, with a corresponding reduction in serum antibody titers, all eight cats were rechallenged with B. henselae. None of the cats became bacteremic after secondary challenge, and all had higher and more rapid increases in serum antibody titers than after primary inoculation. The cats became resistant to reinfection following recovery from infection, indicating that immunoprophylaxis in cats might be beneficial in helping to reduce their public health risk.
通过实验接种，在八只不同年龄的猫身上建立了汉赛巴尔通体感染。所有猫在初次接种后4至7周接受治疗前一直处于持续性菌血症状态。所有猫的抗体滴度均升高，并在4至12周达到峰值。用强力霉素治疗1周对所有猫抑制菌血症有效，但仅对四只猫清除感染有效。随后给予阿莫西林，对其余三只猫清除感染有效。一只持续菌血症的小猫用恩诺沙星治疗无效，用克拉维酸-阿莫西林联合治疗后菌血症最终得以清除。菌血症清除后，血清抗体滴度相应降低，所有八只猫再次用汉赛巴尔通体进行攻击。二次攻击后没有一只猫发生菌血症，并且所有猫血清抗体滴度的升高都比初次接种后更高、更快。猫从感染中恢复后对再次感染产生抗性，这表明对猫进行免疫预防可能有助于降低其对公共卫生的风险。
