Sanberg P R, Borlongan C V, Saporta S, Cameron D F
Department of Surgery, University of South Florida College of Medicine, Tampa 33612, USA.
Nat Biotechnol. 1996 Dec;14(13):1692-5. doi: 10.1038/nbt1296-1692.
Transplantation of neural tissue into the mammalian central nervous system has become an alternative treatment for neurodegenerative disorders such as Parkinson's disease. Logistical and ethical problems in the clinical use of human fetal neural grafts as a source of dopamine for Parkinson's disease patients has hastened a search for successful ways to use animal dopaminergic cells for human transplantation. The present study demonstrates that transplanted testis-derived Sertoli cells into adult rat brains survive. Furthermore, when cotransplanted with bovine adrenal chromaffin cells (xenograft), Sertoli cells produce localized immunoprotection, suppress microglial response and allow the bovine cells to survive in the rat brain without continuous systemic immunosuppressive drugs. These novel features support Sertoli cells as a viable graft source for facilitating the use of xenotransplantation for Parkinson's disease and suggest their use as facilitators, (i.e., localized immunosuppression) for cell transplantation in general.
将神经组织移植到哺乳动物中枢神经系统已成为治疗帕金森病等神经退行性疾病的一种替代疗法。将人类胎儿神经移植物作为帕金森病患者多巴胺来源进行临床应用时存在后勤和伦理问题，这加速了寻找成功利用动物多巴胺能细胞进行人类移植的方法。本研究表明，移植到成年大鼠脑内的睾丸来源的支持细胞能够存活。此外，当与牛肾上腺嗜铬细胞（异种移植物）共同移植时，支持细胞产生局部免疫保护作用，抑制小胶质细胞反应，并使牛细胞在大鼠脑内存活，而无需持续使用全身性免疫抑制药物。这些新特性支持将支持细胞作为一种可行的移植物来源，以促进帕金森病异种移植的应用，并表明它们可作为一般细胞移植的促进剂（即局部免疫抑制）。
