Przepiorka D, Srivastava P K
Baylor College of Medicine, Center for Cell and Gene Therapy, Houston, TX 77030, USA.
Mol Med Today. 1998 Nov;4(11):478-84. doi: 10.1016/s1357-4310(98)01345-8.
Heat shock proteins (Hsps), ubiquitous in nature, act as chaperones for peptides and other proteins. They have been implicated in loading immunogenic peptides onto major histocompatibility complex molecules for presentation to T cells. When isolated from tumor cells, Hsps are complexed with a wide array of peptides, some of which serve as tumor-specific antigens. Animal studies have demonstrated that heat shock protein--peptide complexes (HSPPCs) from tumor cells can act as vaccines to prevent or treat tumors. Potent and specific tumor antigens have long been the holy grail in cancer immunotherapy; HSPPCs from tumor cells could become a safe and reliable source of tumor-specific antigens for clinical application.
热休克蛋白（Hsps）在自然界中广泛存在，作为肽和其他蛋白质的伴侣蛋白发挥作用。它们参与将免疫原性肽加载到主要组织相容性复合体分子上，以便呈递给T细胞。当从肿瘤细胞中分离出来时，热休克蛋白与多种肽结合，其中一些肽充当肿瘤特异性抗原。动物研究表明，来自肿瘤细胞的热休克蛋白-肽复合物（HSPPCs）可以作为疫苗预防或治疗肿瘤。强效且特异性的肿瘤抗原长期以来一直是癌症免疫治疗的圣杯；来自肿瘤细胞的热休克蛋白-肽复合物可能成为临床应用中安全可靠的肿瘤特异性抗原来源。
