Hadjantonakis A K, Formstone C J, Little P F
Wolfson Laboratories, Department of Biochemistry, Imperial College of Science, Technology and Medicine, London SW7 2AZ, UK.
Mech Dev. 1998 Nov;78(1-2):91-5. doi: 10.1016/s0925-4773(98)00153-1.
Mcelsr1 encodes a protein of 3034 amino acids predicted to contain seven membrane spanning domains having homology to a group of peptide hormone binding G-protein coupled receptors. Its extracellular domain comprises epidermal growth factor-like repeats, laminin A G-domains and cadherin repeats. Homologous genes have been identified in C. elegans and D. melanogaster suggesting that the Celsr gene family is ancient. mCelsr1 mRNA expression precedes gastrulation, is subsequently restricted primarily to ectodermal derivatives and is tightly regulated in the developing central nervous system (CNS). We observe segmentally-restricted gene expression in the developing hindbrain and in the spinal cord dynamic dorso-ventrally restricted 'stripes' of expression.
Mcelsr1编码一种由3034个氨基酸组成的蛋白质，预计含有七个跨膜结构域，与一组肽激素结合G蛋白偶联受体具有同源性。其细胞外结构域包括表皮生长因子样重复序列、层粘连蛋白A G结构域和钙黏蛋白重复序列。在秀丽隐杆线虫和黑腹果蝇中已鉴定出同源基因，这表明Celsr基因家族很古老。mCelsr1 mRNA的表达先于原肠胚形成，随后主要局限于外胚层衍生物，并在发育中的中枢神经系统（CNS）中受到严格调控。我们在发育中的后脑和脊髓中观察到节段性受限的基因表达，以及在脊髓中动态的背腹受限的“条纹”状表达。
