Bell J D, Bhakoo K K
MR Unit, Hammersmith Hospital, London, UK.
NMR Biomed. 1998 Nov;11(7):354-9. doi: 10.1002/(sici)1099-1492(1998110)11:7<354::aid-nbm515>3.0.co;2-n.
Magnetic resonance spectroscopy (MRS) remains the technique of choice for observing tumour metabolism non-invasively. Although initially 31P MR spectroscopy showed much promise as a non-invasive diagnostic tool, studies of a wide range of hepatic tumours have conclusively shown that this technique cannot be utilized to distinguish between different tumour types. This lack of specificity and sensitivity appears to be a consequence of the fact that hepatic tumours develop with a range of modalities and not as a single abnormal disease process, and also because of the limited availability of MR detectable metabolic markers. This has led, in recent years, to a re-evaluation of the role of 31P MR spectroscopy, re-emerging as a non-invasive tool to follow the efficacy of the treatment regime. Furthermore, since the principal changes observed in tumours by 31P MRS appear to be an elevation in the concentration of phosphorylcholine (PCho) and phosphoethanolamine (PEth), new research using a combination of MRS and tissue culture of cell lines which carry a combination of known inducible oncogenes, are helping to elucidate some of the metabolic pathways that give rise to these metabolic alterations.
磁共振波谱（MRS）仍然是无创观察肿瘤代谢的首选技术。尽管最初31P磁共振波谱作为一种无创诊断工具显示出很大的前景，但对多种肝肿瘤的研究最终表明，该技术无法用于区分不同的肿瘤类型。这种缺乏特异性和敏感性似乎是由于肝肿瘤以多种方式发展，而非单一的异常疾病过程，同时也由于磁共振可检测代谢标志物的可用性有限。近年来，这导致了对31P磁共振波谱作用的重新评估，它重新成为一种跟踪治疗方案疗效的无创工具。此外，由于31P MRS在肿瘤中观察到的主要变化似乎是磷酸胆碱（PCho）和磷酸乙醇胺（PEth）浓度的升高，使用MRS与携带已知可诱导致癌基因组合的细胞系组织培养相结合的新研究，有助于阐明导致这些代谢改变的一些代谢途径。
