Bell J D, Cox I J, Sargentoni J, Peden C J, Menon D K, Foster C S, Watanapa P, Iles R A, Urenjak J
NMR Unit, Hammersmith Hospital, London, UK.
Biochim Biophys Acta. 1993 Nov 25;1225(1):71-7. doi: 10.1016/0925-4439(93)90124-j.
Spectral changes in human hepatic tumours and possible systemic effects of tumour on host liver were assessed by 31P and 1H in vitro NMR spectroscopy. The 1H and 31P spectra from liver tumour biopsies showed significant elevation in phosphoethanolamine, phosphocholine, taurine, citrate, alanine, lactate and glycine, and significant reduction in GPE (glycerophosphoethanolamine), GPC (glycerophosphocholine), creatine and threonine compared to histologically normal tissue. 31P-NMR spectra obtained from histologically normal tissue within tumour-bearing livers showed significant elevation in phosphoethanolamine and phosphocholine compared to data from liver biopsies from nontumour-bearing patients (pancreatitis). These results suggest that alterations in membrane metabolism in host liver can be detected by 31P-NMR.
通过31P和1H体外核磁共振波谱法评估了人类肝脏肿瘤的光谱变化以及肿瘤对宿主肝脏可能产生的全身影响。与组织学正常组织相比，肝脏肿瘤活检的1H和31P光谱显示磷酸乙醇胺、磷酸胆碱、牛磺酸、柠檬酸盐、丙氨酸、乳酸盐和甘氨酸显著升高，而甘油磷酸乙醇胺（GPE）、甘油磷酸胆碱（GPC）、肌酸和苏氨酸显著降低。与非荷瘤患者（胰腺炎）肝脏活检数据相比，荷瘤肝脏中组织学正常组织的31P-NMR光谱显示磷酸乙醇胺和磷酸胆碱显著升高。这些结果表明，31P-NMR可以检测到宿主肝脏膜代谢的改变。
