急性肝衰竭患者血浆对分离的兔肝细胞的细胞毒性。
The cytotoxicity of plasma from patients with acute hepatic failure to isolated rabbit hepatocytes.
作者信息
Hughes R D, Cochrane A M, Thomson A D, Murray-Lyon I M, Williams R
出版信息
Br J Exp Pathol. 1976 Jun;57(3):348-53.
Abstract
The cytotoxicity of plasma from patients with various types of liver disease to rabbit hepatocytes maintained in vitro has been investigated using a microcytotoxicity assay system. Plasma from patients with fulminant hepatic failure and uncomplicated viral hepatitis showed significant cytotoxicity compared to controls. The cytotoxic effect of plasma from patients with fulminant hepatic failure was reduced by charcoal haemoperfusion, or heating and dialysis. The bile acids chenodeoxycholic acid and lithocholic acid were cytotoxic when added to control human plasma. Such toxic factors may be responsible for the delay in liver regeneration often seen in patients with fulminant hepatic failure.
摘要
利用微细胞毒性检测系统，研究了各类肝病患者的血浆对体外培养的兔肝细胞的细胞毒性。与对照组相比，暴发性肝衰竭患者和无并发症的病毒性肝炎患者的血浆显示出显著的细胞毒性。暴发性肝衰竭患者血浆的细胞毒性作用可通过血液灌流活性炭、加热或透析而降低。鹅去氧胆酸和石胆酸这两种胆汁酸添加到正常人血浆中时具有细胞毒性。这类毒性因子可能是暴发性肝衰竭患者常出现肝再生延迟的原因。
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