Kollins Scott H, Shapiro Steven K, Newland M C, Abramowitz Ann
Western Michigan U.
Exp Clin Psychopharmacol. 1998 Nov;6(4):375-389. doi: 10.1037/1064-1297.6.4.375.
Despite the demonstrated beneficial effects of methylphenidate and d-amphetamine for the treatment of attention-deficit hyperactivity disorder (ADHD), the discriminative and subjective effects of these compounds in children are not well understood. This study was designed to characterize such effects in children diagnosed with ADHD. In a series of 3 experiments, 17 children were examined to determine whether methylphenidate (n = 12) and d-amphetamine (n = 5) could be reliably discriminated at doses typically used in clinical practice. Under some conditions (e.g., when they were instructed to attend to the drug effects or when a wide range of doses was used), children discriminated methylphenidate (5.0-30.0 mg) from placebo. Children tested under a range of doses of d-amphetamine (2.5-20.0 mg) were unable to discriminate this drug from placebo reliably. Neither methylphenidate nor d-amphetamine produced reliable participant-rated effects.
尽管已证明哌甲酯和右旋苯丙胺对治疗注意力缺陷多动障碍（ADHD）有有益效果，但这些化合物在儿童中的辨别性和主观效应尚未得到充分了解。本研究旨在明确被诊断患有ADHD的儿童的此类效应。在一系列3个实验中，对17名儿童进行了检查，以确定哌甲酯（n = 12）和右旋苯丙胺（n = 5）在临床实践中常用剂量下是否能够被可靠辨别。在某些条件下（例如，当他们被指示留意药物效应或使用了广泛的剂量范围时），儿童能够辨别哌甲酯（5.0 - 30.0毫克）与安慰剂。在一系列右旋苯丙胺剂量（2.5 - 20.0毫克）下接受测试的儿童无法可靠地辨别该药物与安慰剂。哌甲酯和右旋苯丙胺均未产生可靠的受试者评定效应。
