Martin Catherine A, Guenthner Greg, Bingcang Christopher, Rayens Mary Kay, Kelly Thomas H
Department of Psychiatry, University of Kentucky College of Medicine, Lexington, Kentucky 40509, USA.
J Child Adolesc Psychopharmacol. 2007 Feb;17(1):63-73. doi: 10.1089/cap.2006.0020.
This study examined subjective and other behavioral effects of methylphenidate (MPH) among adolescents.
Standard abuse liability assessment methods that have been used in adult populations were modified for attention-deficit/hyperactivity disorder (ADHD) adolescents. MPH effects (0, 0.25 mg/kg) were evaluated under randomized, double-blind conditions in two 5-hour laboratory sessions in 24 (13 female) 11-15 year olds diagnosed with ADHD.
Repeated measures analysis of covariance indicated significant dose and dose by time interactions on subjective ratings on the modified amphetamine (A) [F (1, 20) = 5.98; p < 0.05; eta2 = 0.36], morphine-benzedrine group (MBG) [F (1, 21) = 8.93 p < 0.01; eta2 = 0.38] and benzedrine group scale (BG) [F (1, 21) + 13.10 p < 0.01; eta2 = 0.37] scales of the Addiction Research Center Inventory; "Hungry" and "How sure are you that you got the medication today?" from the Visual Analogue Scale, the Profile of Mood States Depression scale, performance on the Continuous Performance Task, heart rate and blood pressure, and level of activity.
This is the first study to document subjective effects of stimulants in adolescents with ADHD that have been associated with drug abuse potential in adults. There are increasing concerns about nontherapeutic stimulant use in adolescents and young adults. Assessing subjective effects of pharmacotherapies for ADHD along with other measures of abuse potential such as drug self-administration may aid in assessing the therapeutic effects and/or risk of medications used in the treatment of ADHD.
本研究考察了哌甲酯（MPH）对青少年的主观及其他行为影响。
针对注意力缺陷多动障碍（ADHD）青少年，对已用于成年人群的标准药物滥用可能性评估方法进行了修改。在随机、双盲条件下，对24名（13名女性）11 - 15岁被诊断为ADHD的青少年进行了两个5小时的实验室测试，评估MPH（0、0.25 mg/kg）的效果。
重复测量协方差分析表明，在成瘾研究中心量表的改良苯丙胺（A）[F（1, 20） = 5.98；p < 0.05；η² = 0.36]、吗啡 - 苯丙胺组（MBG）[F（1, 21） = 8.93，p < 0.01；η² = 0.38]和苯丙胺组量表（BG）[F（1, 21） + 13.10，p < 0.01；η² = 0.37]上，剂量及剂量与时间的交互作用对主观评分有显著影响；视觉模拟量表中的“饥饿”和“你有多确定今天服用了药物？”、情绪状态剖面图抑郁量表、持续性操作任务表现、心率和血压以及活动水平。
这是第一项记录兴奋剂对ADHD青少年主观影响的研究，这些影响在成年人中与药物滥用可能性相关。人们越来越关注青少年和年轻人非治疗性使用兴奋剂的情况。评估ADHD药物治疗的主观影响以及其他药物滥用可能性指标，如药物自我给药，可能有助于评估用于治疗ADHD的药物的治疗效果和/或风险。
