Dzielska-Olczak M, Polakowski P, Kubik-Bogucka E
Department of Pharmacology, Medical University of Lódź, Poland.
Pol J Pharmacol. 1998 May-Jun;50(3):225-31.
The present study was undertaken to investigate the influence of captopril and enalaprilat--two different angiotensin converting enzyme (ACE) inhibitors--on experimental cardiac arrhythmias induced by barium chloride, ouabain or adrenaline. The research was carried out on rabbits. Captopril and enalaprilat were administered only once. Arrhythmias were evoked by three different doses of arrhythmogens: ED50 and two higher ones causing rhythm disturbances in 80-100% rabbits. The patterns of arrhythmias as well as their frequency and duration were evaluated on the basis of ECG examination. The results were subjected to statistic analysis. As a result of our research, we were able to establish that ACE inhibitors, when administered at a single dose, did not influence the patterns but changed the frequency and duration of barium chloride-, adrenaline- or ouabain-induced arrhythmias. Captopril and enalaprilat administered at a single dose decreased the frequency of barium chloride- or ouabain- but not adrenaline-induced arrhythmia. A single administration of captopril and enalaprilat limit the duration of arrhythmias caused by barium chloride, ouabain or adrenaline.
本研究旨在探讨两种不同的血管紧张素转换酶（ACE）抑制剂——卡托普利和依那普利拉，对氯化钡、哇巴因或肾上腺素诱发的实验性心律失常的影响。该研究以家兔为实验对象。卡托普利和依那普利拉仅给药一次。通过三种不同剂量的致心律失常药物诱发心律失常：半数有效剂量（ED50）以及另外两种能使80 - 100%家兔出现节律紊乱的更高剂量。基于心电图检查评估心律失常的类型、频率和持续时间。对结果进行统计学分析。我们的研究结果表明，ACE抑制剂单次给药时，不会影响心律失常的类型，但会改变氯化钡、肾上腺素或哇巴因诱发的心律失常的频率和持续时间。单次给予卡托普利和依那普利拉可降低氯化钡或哇巴因诱发的心律失常频率，但对肾上腺素诱发的心律失常频率无影响。单次给予卡托普利和依那普利拉可缩短氯化钡、哇巴因或肾上腺素所致心律失常的持续时间。
