Makarewicz-Płońska M, Witek A, Farbiszewski R
Department of Analytical Chemistry, Medical University, Białystok, Poland.
Pol J Pharmacol. 1998 May-Jun;50(3):265-9.
The purpose of our experiments was to determine whether BN 52021, PAF-receptor antagonist, has any influence on the production of reactive oxygen species in the lung induced by haemorrhagic shock. The results showed, that the activities of Cu,Zn-superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) in the lung after haemorrhagic shock were decreased in comparison with control and sham groups while the activity of glutathione reductase (GSSG-R) was unchanged. The content of SH-groups was decreased while thiobarbituric acid reacting substances (TBA-rs) after haemorrhagic shock were increased. Infusion of BN 52021 (5.0 mg/kg i.v.) in haemorrhagic animals caused significantly increased activities of Cu,Zn-SOD, GSH-Px, GSSG-R in the lung. The SH-group level was slightly increased while TBA-rs returned to normal values.
我们实验的目的是确定血小板活化因子受体拮抗剂BN 52021是否对失血性休克诱导的肺中活性氧的产生有任何影响。结果显示，与对照组和假手术组相比，失血性休克后肺中铜锌超氧化物歧化酶（SOD）和谷胱甘肽过氧化物酶（GSH-Px）的活性降低，而谷胱甘肽还原酶（GSSG-R）的活性未改变。巯基含量降低，而失血性休克后硫代巴比妥酸反应物质（TBA-rs）增加。对失血性动物静脉注射BN 52021（5.0毫克/千克）可使肺中铜锌SOD、GSH-Px、GSSG-R的活性显著增加。巯基水平略有升高，而TBA-rs恢复到正常水平。
