Hartmann M, Jansen O, Egelhof T, Forsting M, Albert F K, Sartor K
Abteilung Neuroradiologie, Universitätsklinik Heidelberg.
Radiologe. 1998 Nov;38(11):948-53. doi: 10.1007/s001170050447.
To assess the influence of initial preoperative brain edema in malignant gliomas on regrowth patterns.
79 patients with histologically verified supratentorial malignant glioma were prospectively studied by magnetic resonance imaging (MRI) before and every 2-3 months after surgery. The median follow-up time was 11 months. We correlated the configuration of the initial vasogenic edema on T2-weighted images with tumor regrowth patterns on contrast-enhanced T1-weighted images.
35/47 tumor regrowths (75%) imitated the initial edema configuration, while 11/47 occurred within the initial tumor bed; in one case tumor recurrence was multilocal.
In glioblastoma, tumor regrowth patterns correlate positively with the configuration of the initial vasogenic brain edema. The initial, "presurgical" peritumoral edema should thus be considered when planning further treatment.
评估恶性胶质瘤术前初始脑水肿对肿瘤复发模式的影响。
对79例经组织学证实的幕上恶性胶质瘤患者进行前瞻性研究，术前及术后每2 - 3个月行磁共振成像（MRI）检查。中位随访时间为11个月。我们将T2加权图像上初始血管源性水肿的形态与增强T1加权图像上的肿瘤复发模式进行关联分析。
47例肿瘤复发中有35例（75%）模仿了初始水肿形态，11例复发位于初始肿瘤床内；1例肿瘤复发为多灶性。
在胶质母细胞瘤中，肿瘤复发模式与初始血管源性脑水肿形态呈正相关。因此，在规划进一步治疗时应考虑初始的“术前”瘤周水肿情况。
