Holmes S C, Burden A D
University Department of Dermatology, Western Infirmary, Glasgow, Scotland.
Clin Exp Dermatol. 1998 May;23(3):129-31. doi: 10.1046/j.1365-2230.1998.00354.x.
There has long been controversy concerning the relationship between lichen planus and lichen sclerosus. Whilst these two conditions are now considered distinct, there are shared clinical and pathological features. We now describe two patients with the cutaneous involvement of both lichen planus and lichen sclerosus, presenting a review of similar reported cases and discussing the implications for pathogenesis of these two diseases. Neither lichen planus (LP) nor lichen sclerosus (LS) are uncommon yet they have only infrequently been reported as coexisting. In his original description of LS, however, Hallopeau considered it to be a variant of LP and Gougerot has also commented on a possible common pathogenesis for the two conditions. Features which tend to support such as association include the distribution of the cutaneous lesions, histopathological features such as hydropic basal cell degeneration and a band-like lymphohistiocytic infiltrate in the dermis, and the reported association with autoimmune disease. We now report two patients in whom coexistent cutaneous LS and LP was confirmed histologically.
长期以来，扁平苔藓与硬化性苔藓之间的关系一直存在争议。虽然现在认为这两种疾病是不同的，但它们有一些共同的临床和病理特征。我们现在描述两名同时患有扁平苔藓和硬化性苔藓皮肤受累的患者，回顾类似的报道病例，并讨论这两种疾病发病机制的相关问题。扁平苔藓（LP）和硬化性苔藓（LS）都并不罕见，但它们同时存在的情况却鲜有报道。然而，在Hallopeau对LS的最初描述中，他认为LS是LP的一种变体，Gougerot也评论过这两种疾病可能存在共同的发病机制。倾向于支持这种关联的特征包括皮肤病变的分布、组织病理学特征，如基底细胞水肿性变性和真皮层带状淋巴细胞-组织细胞浸润，以及与自身免疫性疾病的报道关联。我们现在报告两名经组织学证实同时存在皮肤LS和LP的患者。
