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法属西印度群岛严重肢体缺血的外科治疗

Surgical management of critical limb ischaemia in the French West Indies.

作者信息

Deneuville M

机构信息

Division of Vascular and Thoracic Surgery, Centre Hospitalo-Universitaire, Pointe-à-Pitre, Guadeloupe, FWI.

出版信息

West Indian Med J. 1998 Sep;47(3):94-7.

PMID:9861859
Abstract

This retrospective study analyses the clinical presentation, surgical management and early outcome of 174 patients (mean age +/- SEM: 73 +/- 15 yrs) admitted for critical limb ischaemia. 145 (84%) had tissue loss at admission: toe gangrene or ischaemic ulcer in 77, and gangrene extending beyond the forefoot in 68. 87 primary limb amputations and 107 revascularisations were performed at iliofemoral (n = 20), suprapopliteal (n = 22) or infrapopliteal level. The postoperative mortality rate was 14% in the "Amputation" group and 9% in the "Revascularisation" group but the difference was not statistically significant. Infective complications were comparable in both groups, although 5 of 14 deaths after amputation were directly related to infection and all deaths after revascularisation resulted from cardiovascular complications. The early limb salvage rate after revascularisation was 82%. 19 secondary limb amputations were performed for bypass failure. Patients in whom primary amputations were required were older (p < 0.03) and had significantly higher rates of heart disease and nonambulatory status (respectively, 24 vs 17%, p < 0.05; and 37 vs 13%, p < 0.001) than patients in whom revascularisation was performed. Ischaemic rest pain and tissue loss confined to digit gangrene or ischaemic ulcer occurred more frequently than extensive gangrene in the "Revascularisation" group (p < 0.0001), while extensive gangrene extending beyond the forefoot occurred more frequently than ischaemic rest pain and tissue loss in the "Amputation" group (p < 0.0001). Late presentation of patients and enhanced tissue loss are probably the reasons for the higher primary amputation rate in our patients compared to that observed elsewhere. In patients amenable to revascularisation (56%), arterial reconstruction for critical limb ischaemia improves the chances of limb salvage.

摘要

这项回顾性研究分析了174例因严重肢体缺血入院患者(平均年龄±标准误:73±15岁)的临床表现、手术治疗及早期预后。145例(84%)入院时存在组织缺损:77例为趾坏疽或缺血性溃疡,68例坏疽范围超过前足。在髂股(n = 20)、腘上(n = 22)或腘下水平进行了87例一期肢体截肢和107例血管重建术。“截肢”组术后死亡率为14%,“血管重建”组为9%,但差异无统计学意义。两组感染并发症相当,尽管截肢后14例死亡中有5例直接与感染相关,血管重建术后所有死亡均由心血管并发症导致。血管重建术后早期肢体挽救率为82%。因旁路失败进行了19例二期肢体截肢。需要进行一期截肢的患者年龄更大(p < 0.03),心脏病发生率和非行走状态发生率显著更高(分别为24%对17%,p < 0.05;37%对13%,p < 0.001),高于接受血管重建术的患者。“血管重建”组中缺血性静息痛和局限于趾坏疽或缺血性溃疡的组织缺损比广泛坏疽更常见(p < 0.0001),而“截肢”组中超过前足的广泛坏疽比缺血性静息痛和组织缺损更常见(p < 0.0001)。与其他地方观察到的情况相比,患者就诊延迟和组织缺损增加可能是我们患者中一期截肢率较高的原因。在适合血管重建的患者(56%)中,针对严重肢体缺血进行动脉重建可提高肢体挽救的机会。

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