Leder K, Turnidge J D, Grayson M L
Infectious Disease and Clinical Epidemiology Department, Monash Medical Centre, Melbourne, VIC.
Med J Aust. 1998 Nov 16;169(10):519-22. doi: 10.5694/j.1326-5377.1998.tb123398.x.
To assess the clinical outcome and pharmacokinetics of therapy with cefazolin for patients with cellulitis in a hospital-in-the-home (HIH) program.
Observational study with outcome data compared with previously published reports of therapy for cellulitis.
A university teaching hospital and HIH unit, July 1996-December 1997.
Patients with cellulitis were eligible for inclusion provided their medical condition was stable, they did not require surgical intervention, and their social circumstances allowed home-based therapy.
Cefazolin 2 g intravenously twice daily, with regular nursing and medical assessment.
Clinical efficacy; peak and trough serum concentrations of cefazolin.
Fifty-seven patients (37 were men) with a mean age of 48 years (range, 18-90 years) had 61 episodes of moderate to severe cellulitis (41, lower limb; 17, upper limb; and three, face). They received a median of 11 doses of cefazolin (range, 3-27 doses). Clinical outcomes were: cure in 54, improvement in one, treatment failure in three, and in the remaining three episodes the outcome was indeterminate. Cefazolin concentrations were measured in 27 patients. All peak concentrations were more than 40 micrograms/mL, while trough concentrations were all above the MIC90 of the expected pathogens: median, 3.2 micrograms/mL (range: 0.4-18.5 micrograms/mL). Cefazolin was well tolerated.
Twice-daily cefazolin 2 g intravenously is a convenient and effective option for home-based treatment of patients with cellulitis. Its clinical efficacy is comparable with other treatment regimens.
评估在家庭医院（HIH）项目中，使用头孢唑林治疗蜂窝织炎患者的临床疗效和药代动力学。
观察性研究，将结果数据与先前发表的蜂窝织炎治疗报告进行比较。
一所大学教学医院及家庭医院病房，1996年7月至1997年12月。
蜂窝织炎患者若病情稳定、无需手术干预且社会情况允许居家治疗，则符合纳入条件。
静脉注射头孢唑林2g，每日两次，并进行定期护理和医学评估。
临床疗效；头孢唑林的血清峰浓度和谷浓度。
57例患者（3
