Visser N A, de Koning M H, Lammi M J, Häkkinen T, Tammi M, van Kampen G P
Jan van Breemen Institute, Amsterdam, The Netherlands.
Connect Tissue Res. 1998;37(3-4):295-302. doi: 10.3109/03008209809002446.
The effect of long distance running exercise (40 km/day for 15 weeks, five days a week) on the decorin content of articular cartilage from the knee joint was studied in female beagle dogs. Samples from load bearing sites on the lateral plateau of the tibia (TL), and pooled material from two minimum load bearing sites on the posterior section of lateral (FLP) and medial (FMP) femoral condyles were analyzed. The running exercise protocol did not lead to significant changes in the overall glycosaminoglycan content of the cartilage. However, the amount of decorin significantly increased in the TL samples, and also in the FMP pool. These results support earlier in vitro observations that decorin synthesis is stimulated by loading, independent of the synthesis of aggrecan.
在雌性比格犬中研究了长跑运动（每周五天，每天40公里，共15周）对膝关节软骨中核心蛋白聚糖含量的影响。分析了来自胫骨外侧平台承重部位（TL）的样本，以及来自外侧（FLP）和内侧（FMP）股骨髁后部两个最小承重部位的合并材料。跑步运动方案并未导致软骨总体糖胺聚糖含量发生显著变化。然而，TL样本以及FMP合并样本中核心蛋白聚糖的含量显著增加。这些结果支持了早期的体外观察结果，即核心蛋白聚糖的合成受负荷刺激，与聚集蛋白聚糖的合成无关。
