膳食多胺是小肠和结肠黏膜生长发育所必需的腔内生长因子。
Dietary polyamines are essential luminal growth factors for small intestinal and colonic mucosal growth and development.
作者信息
Löser C, Eisel A, Harms D, Fölsch U R
机构信息
I Medical Department, Christian-Albrechts University, Schittenhelmstrasse 12, D-24105 Kiel, Germany.
出版信息
Gut. 1999 Jan;44(1):12-6. doi: 10.1136/gut.44.1.12.
BACKGROUND
Polyamines are essential for cell growth. Dietary and probably gut bacterial derived polyamines contribute significantly to the polyamine body pool.
AIMS
To evaluate the influence of dietary, luminal polyamines on growth and development of different gastrointestinal organs in normally growing rats.
METHODS
Male suckling Wistar rats were randomly allocated to four treatment groups: polyamine deficient diet (PDD); PDD plus antibiotics (neomycin 2 g/kg and metronidazole 34 mg/kg); PDD plus polyamine supplementation at normal concentrations; or normal standard laboratory chow. After a six month feeding period 7-10 animals/group were sacrificed.
RESULTS
No differences in body weight gain, food consumption, or general behaviour could be observed between the four groups of animals. Feeding of PDD alone or PDD plus antibiotics resulted in a highly significant decrease in organ weight, protein content, and DNA content in small intestinal and colonic mucosa whereas no alterations were found in the liver.
CONCLUSIONS
Long term feeding of polyamine deficient diets resulted in a significant hypoplasia of small intestinal and colonic mucosa. Dietary, luminal polyamines are important local factors for growth and the development of small intestinal and colonic mucosa.
背景
多胺对细胞生长至关重要。饮食中以及可能来自肠道细菌的多胺对多胺体内储备有显著贡献。
目的
评估饮食中的肠腔多胺对正常生长大鼠不同胃肠道器官生长发育的影响。
方法
将雄性哺乳期Wistar大鼠随机分为四个治疗组：多胺缺乏饮食组（PDD）；PDD加抗生素组（新霉素2 g/kg和甲硝唑34 mg/kg）；PDD加正常浓度多胺补充组；或正常标准实验室饲料组。经过六个月的喂养期后，每组处死7 - 10只动物。
结果
四组动物之间在体重增加、食物消耗或一般行为方面未观察到差异。单独喂养PDD或PDD加抗生素导致小肠和结肠黏膜的器官重量、蛋白质含量和DNA含量显著降低，而肝脏未发现改变。
结论
长期喂养多胺缺乏饮食导致小肠和结肠黏膜显著发育不全。饮食中的肠腔多胺是小肠和结肠黏膜生长发育的重要局部因素。
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