Li G Q, Fu Y X, Bian W X
Tropical Medicine Institute, Guangzhou University of Traiditional Chinese Medicine.
Zhongguo Zhong Xi Yi Jie He Za Zhi. 1997 Mar;17(3):143-4.
To assess the efficacy of Artesunate on falciparum malaria.
A randomized controlled study on the treatment of 90 uncomplicated falciparum malaria patients was carried out with 400 mg of artesunate tablet as a total dose over 3 days, 600 mg over 5 days and 800 mg over 7 days.
All patients were cured. Fever clearance time (FCT) and parasite clearance time(PCT) among the three groups were similar. Parasite recrudescence rate within 28 days was 39.3% (11/ 28) in 3 day group, 6.9% (2/29) in 5 day group and 3.4% (1/29) in 7 day group (comparing 5 day group with 3 day group, P < 0.005, comparing 7 day group with 3 day group, P < 0.005).
It indicated that parasite recrudescence rate may be effectively decreased by prolonging treatment courses.
评估青蒿琥酯治疗恶性疟的疗效。
对90例非复杂性恶性疟患者进行随机对照研究，总剂量400毫克青蒿琥酯片分3天服用，600毫克分5天服用，800毫克分7天服用。
所有患者均治愈。三组的退热时间（FCT）和寄生虫清除时间（PCT）相似。28天内的寄生虫复发率在3天组为39.3%（11/28），5天组为6.9%（2/29），7天组为3.4%（1/29）（5天组与3天组比较，P<0.005；7天组与3天组比较，P<0.005）。
表明延长疗程可有效降低寄生虫复发率。
