康可注射液对病毒性心肌炎的治疗作用及其抗柯萨奇病毒机制

[Therapeutic effect of kangke injection on viral myocarditis and its anticoxsackie virus mechanism].

作者信息

Chen S X, Mei S W, Wang P Q

机构信息

Renji Hospital, Shanghai Second Medical University.

出版信息

Zhongguo Zhong Xi Yi Jie He Za Zhi. 1997 Apr;17(4):207-9.

PMID:9863092

Abstract

OBJECTIVE

To assess the efficacy of Kangke Injection in treating viral myocarditis.

METHODS

Kangke Injection is the effective ingredient extracted from Radix Sophora flavescens (RSF). Seventy-six cases of virus myocarditis suffering from the continuous positive Coxsackie B virus ribose nucleic acid-polymerase chain reaction (CBVRNA-PCR) in blood, their peak value in blood was determined by high performance liquid chromatography (HPLC) and compared with 50 cases treated by glucose-insulin-potassium chloride (GIK).

RESULTS

The clearance rate of CBVRNA-PCR and RSF was dose-dependent. The effective rate of RSF on palpitation, chest distress, dispnea was 96.02%, and that of arrhythmia was 100%, all of them were better than those of control. After RSF therapy, the parameters of heart function of ejection fraction (EF), stroke volume (SV), cardiac output (CO), and cardiac index (CI) elevated significantly (P < 0.01), left ventricular mass (LVM) and left ventricular mass index (LVMI) were decreased statistically significantly, while after 5 month therapy, the anti-Coxsackie group B virus neutralizing antibodies of RSF group was returned to normal titer, natural killer (NK) cell activity elevated, P < 0.01.

CONCLUSION

RSF was an effective substance for regressing the "Pathologic status" of viral myocarditis.

摘要

目的

评估康克注射液治疗病毒性心肌炎的疗效。

方法

康克注射液是从苦参中提取的有效成分。选取76例血液中柯萨奇B病毒核糖核酸聚合酶链反应（CBVRNA-PCR）持续阳性的病毒性心肌炎患者，采用高效液相色谱法（HPLC）测定其血液中该成分的峰值，并与50例接受葡萄糖-胰岛素-氯化钾（GIK）治疗的患者进行比较。

结果

CBVRNA-PCR的清除率和苦参有效成分呈剂量依赖性。苦参有效成分对心悸、胸闷、气短的有效率为96.02%，对心律失常的有效率为100%，均优于对照组。苦参有效成分治疗后，射血分数（EF）、每搏量（SV）、心输出量（CO）和心脏指数（CI）等心功能参数显著升高（P<0.01），左心室质量（LVM）和左心室质量指数（LVMI）有统计学意义的下降，而治疗5个月后，苦参组抗柯萨奇B病毒中和抗体恢复至正常滴度，自然杀伤（NK）细胞活性升高，P<0.01。