• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

钾通道开放剂对培养的兔主动脉平滑肌细胞增殖的抑制作用。

Inhibitory effect of potassium channel openers on proliferation of cultured rabbit aortic smooth muscle cells.

作者信息

Shi D H, Guo Z G

机构信息

Research Section of Pharmacology, Hu-nan Medical University, Changsha, China.

出版信息

Zhongguo Yao Li Xue Bao. 1996 Nov;17(6):513-5.

PMID:9863144
Abstract

AIM

To study the effects of pinacidil (Pin), nicorandil (Nic), RP 49356 (RP), and lemakalim (Lem) on phenylephrine (PE)-induced proliferation of cultured rabbit aortic smooth muscle cells (ASMC).

METHODS

The [3H]thymidine incorporation into DNA and number of ASMC were measured.

RESULTS

[3H]Thymidine uptake induced by PE was markedly inhibited by Pin, Nic, RP, and Lem (0.1-10 mumol.L-1). Only RP inhibited [3H]thymidine uptake without PE-pretreatment. Cell growth induced by PE was completely inhibited by Pin.

CONCLUSION

Pin, Nic, RP, and Lem showed potent antiproliferation of ASMC.

摘要

目的

研究吡那地尔（Pin）、尼可地尔（Nic）、RP 49356（RP）和雷马卡林（Lem）对去氧肾上腺素（PE）诱导的培养兔主动脉平滑肌细胞（ASMC）增殖的影响。

方法

测定[³H]胸腺嘧啶核苷掺入DNA的量及ASMC的数量。

结果

Pin、Nic、RP和Lem（0.1 - 10 μmol·L⁻¹）显著抑制PE诱导的[³H]胸腺嘧啶核苷摄取。仅RP在无PE预处理时抑制[³H]胸腺嘧啶核苷摄取。Pin完全抑制PE诱导的细胞生长。

结论

Pin、Nic、RP和Lem对ASMC显示出强大的抗增殖作用。

相似文献

1
Inhibitory effect of potassium channel openers on proliferation of cultured rabbit aortic smooth muscle cells.钾通道开放剂对培养的兔主动脉平滑肌细胞增殖的抑制作用。
Zhongguo Yao Li Xue Bao. 1996 Nov;17(6):513-5.
2
Potassium channel openers inhibit ATP-induced cytosolic free calcium increase in cultured rabbit aortic smooth muscle cells.钾通道开放剂可抑制培养的兔主动脉平滑肌细胞中ATP诱导的胞质游离钙增加。
Zhongguo Yao Li Xue Bao. 1996 Mar;17(2):125-8.
3
Inhibitory effect of trapidil on proliferation of cultured rat aortic smooth muscle cells induced by endothelin-1.
Zhongguo Yao Li Xue Bao. 1998 May;19(3):254-6.
4
Potassium channels and human corporeal smooth muscle cell tone: diabetes and relaxation of human corpus cavernosum smooth muscle by adenosine triphosphate sensitive potassium channel openers.钾通道与人体平滑肌细胞张力：糖尿病与三磷酸腺苷敏感性钾通道开放剂对人阴茎海绵体平滑肌的舒张作用
J Urol. 2002 Jul;168(1):355-61.
5
[Inhibitory effects of m-nifedipine on angiotensin II stimulated proliferation and protein synthesis in cultured rabbit aortic smooth muscle cells].
Yao Xue Xue Bao. 1996;31(10):732-6.
6
[Effect of sodium ferulate on proliferation of rabbit aortic smooth muscle cells induced by oxidized LDL].阿魏酸钠对氧化型低密度脂蛋白诱导的兔主动脉平滑肌细胞增殖的影响
Zhongguo Zhong Yao Za Zhi. 1999 Jun;24(6):365-6, 384.
7
Inhibitory effects of captopril on hypoxia-induced proliferation and collagen synthesis in pulmonary vascular smooth muscle cells.卡托普利对缺氧诱导的肺血管平滑肌细胞增殖及胶原合成的抑制作用。
Zhongguo Yao Li Xue Bao. 1999 Apr;20(4):349-52.
8
[Effects of nicardipine and chlorpromazine on proliferation and intracellular calmodulin in cultured aortic smooth muscle cells].
Zhongguo Yao Li Xue Bao. 1990 Sep;11(5):450-4.
9
Effect of captopril on proliferation of aortic smooth muscle cells.卡托普利对主动脉平滑肌细胞增殖的影响。
Zhongguo Yao Li Xue Bao. 1996 Nov;17(6):503-6.
10
Inhibitory effects of purified green tea epicatechins on contraction and proliferation of arterial smooth muscle cells.纯化绿茶表儿茶素对动脉平滑肌细胞收缩和增殖的抑制作用。
Acta Pharmacol Sin. 2000 Sep;21(9):835-40.