Wang Y, Lin M Z, Han G C
Department of Physiology, Dalian Medical University.
Sheng Li Xue Bao. 1997 Dec;49(6):679-84.
The effect of spinal alpha adrenoceptor blockage on the inhibition of renal sympathetic nerve activity (RSNA) and natriuresis induced by blood volume expansion was investigated in anesthetized and bilateral sinoaortic denervated rabbits. In the groups of rabbits with intrathecal injection of alpha-adrenoceptor blocker phentolamine or artificial cerebrospinal fluid the inhibition of RSNA induced by blood volume expansion were (-25.4 +/- 5.4)% and (-42.5 +/- 5.2)% respectively (P < 0.05). In the groups of rabbits with intrathecal injection of alpha 1 adtenoceptor blocker prazosin or artificial cerebrospinal fluid the inhibition of RSNA induced by blood volume expansion were (-29.3 +/- 6.1)% and (-42.5 +/- 5.2)% respectively (P < 0.05). These results suggested that both spinal alpha and alpha 1 adrenceptor blockage with attenuated the inhibition of RSNA induced by blood volume expansion. The spinal alpha 1 adrenceptor blockage with intrathecal injection of prazosin also attenuated signiticantly the natriuresis and diuresis induced by blood volume expansion (P < 0.05).
在麻醉且双侧窦神经切除的家兔中，研究了脊髓α肾上腺素能受体阻滞对血容量扩张诱导的肾交感神经活动（RSNA）抑制和利钠作用的影响。在鞘内注射α肾上腺素能受体阻滞剂酚妥拉明或人工脑脊液的家兔组中，血容量扩张诱导的RSNA抑制分别为（-25.4±5.4）%和（-42.5±5.2）%（P<0.05）。在鞘内注射α1肾上腺素能受体阻滞剂哌唑嗪或人工脑脊液的家兔组中，血容量扩张诱导的RSNA抑制分别为（-29.3±6.1）%和（-42.5±5.2）%（P<0.05）。这些结果表明，脊髓α和α1肾上腺素能受体阻滞均减弱了血容量扩张诱导的RSNA抑制。鞘内注射哌唑嗪进行脊髓α1肾上腺素能受体阻滞也显著减弱了血容量扩张诱导的利钠和利尿作用（P<0.05）。
