Fujimoto M, Ohgo T, Igarashi T, Ohtake S
Nihon Yakurigaku Zasshi. 1976;72(1):15-21. doi: 10.1254/fpj.72.15.
The present study was performed in order to determine protective effect of dl-alpha-tocopheryl nictonate (EN) and dl-alpha-tocopheryl acetate (EA) on pulmonary edema induced by epinephrine (Epi) in mice. The tocopheryl esters were orally administered once a day for 10 days. Epi was then infused to induce pulmonary edema 3 hr after the final dosing. One or three min infusion of 0.01% Epi at a rate of 0.1 ml/min provoked toxic syndromes as pilorection, exophthalmos and salivation. Some animals died of respiratory failure. The lung weight either wet or dry increased after the EPi infusion and diffuse hemorrhage into alveoles was microscopically recognized in untreated animals. However, these findings were of lesser degree in animals receiving NE (20, 50 and 100 mg/kg/day) and Ea (corresponding doses with EN in molecular weight basis). When comparing the effect of EN with that of EA on the increase of lung weight and death from the Epi infusion, EN was more protective than EA. Although the mechanism of protecting action of these tocopheryl esters remains obscure, the interpretation is that these compounds did not affect the pressor response to Epi.
进行本研究是为了确定烟酸生育酚酯（EN）和醋酸生育酚酯（EA）对肾上腺素（Epi）诱导的小鼠肺水肿的保护作用。生育酚酯每天口服一次，持续10天。在最后一次给药3小时后，注入Epi以诱导肺水肿。以0.1 ml/min的速度输注0.01%的Epi 1或3分钟会引发诸如竖毛、眼球突出和流涎等中毒症状。一些动物死于呼吸衰竭。在未治疗的动物中，注入Epi后肺的湿重和干重均增加，并且在显微镜下可观察到肺泡内弥漫性出血。然而，在接受NE（20、50和100 mg/kg/天）和EA（与EN基于分子量的相应剂量）的动物中，这些发现的程度较轻。当比较EN和EA对Epi输注引起的肺重量增加和死亡的影响时，EN的保护作用比EA更强。尽管这些生育酚酯的保护作用机制仍不清楚，但可以解释为这些化合物不影响对Epi的升压反应。
