Nitta Y, Kamiya K, Tanimoto M, Sadamoto S, Niwa O, Yokoro K
Department of Pathology, Research Institute for Nuclear Medicine and Biology, Hiroshima University.
Jpn J Cancer Res. 1991 May;82(5):511-7. doi: 10.1111/j.1349-7006.1991.tb01880.x.
Natural vitamin E and synthetic vitamin E (dl-alpha-tocopheryl acetate) were tested for their tumorigenicity in rodents. Transplantable tumors, at the site of injection, were induced by repeated injections of these compounds in two strains of mice, NFS/N and C57BL/6N x C3H/He F1, and in a strain of rats, Fischer 344. Natural vitamin E was tumorigenic in both strains of female mice only when injected with soya oil. In contrast, dl-alpha-tocopheryl acetate alone was capable of inducing tumors in Fischer 344 rats. Only one out of 5 male NFS/N mice given dl-alpha-tocopheryl acetate developed a tumor. Therefore, Fischer 344 rats were more susceptible to tumor formation by dl-alpha-tocopheryl acetate than NFS/N mice. dl-alpha-Tocopheryl acetate with soya oil or with palm oil also resulted in the formation of transplantable tumors in NFS/N mice and Fischer 344 rats. There was no difference in the tumor incidence between mice treated with dl-alpha-tocopheryl acetate alone and dl-alpha-tocopheryl acetate plus soya oil or palm oil. However, in rats, the incidence was lower for a group treated with dl-alpha-tocopheryl acetate plus palm oil than for those with dl-alpha-tocopheryl acetate alone and with dl-alpha-tocopheryl acetate plus soya oil.
对天然维生素E和合成维生素E（dl-α-生育酚乙酸酯）在啮齿动物中的致瘤性进行了测试。在NFS/N和C57BL/6N×C3H/He F1这两种品系的小鼠以及Fischer 344品系的大鼠中，通过反复注射这些化合物，在注射部位诱发了可移植肿瘤。仅在与大豆油一起注射时，天然维生素E才在两种品系的雌性小鼠中具有致瘤性。相比之下，单独的dl-α-生育酚乙酸酯能够在Fischer 344大鼠中诱发肿瘤。给予dl-α-生育酚乙酸酯的5只雄性NFS/N小鼠中只有1只发生了肿瘤。因此，Fischer 344大鼠比NFS/N小鼠对dl-α-生育酚乙酸酯诱导的肿瘤形成更敏感。dl-α-生育酚乙酸酯与大豆油或棕榈油一起使用时，也会在NFS/N小鼠和Fischer 344大鼠中导致可移植肿瘤的形成。单独使用dl-α-生育酚乙酸酯处理的小鼠与使用dl-α-生育酚乙酸酯加大豆油或棕榈油处理的小鼠之间的肿瘤发生率没有差异。然而，在大鼠中，用dl-α-生育酚乙酸酯加棕榈油处理的组的发生率低于单独使用dl-α-生育酚乙酸酯以及使用dl-α-生育酚乙酸酯加大豆油处理的组。
