HIV 肠道病：居住在英国和乌干达的 HIV 感染患者空肠黏膜的比较形态计量学
HIV enteropathy: comparative morphometry of the jejunal mucosa of HIV infected patients resident in the United Kingdom and Uganda.
作者信息
Batman P A, Kapembwa M S, Miller A R, Sedgwick P M, Lucas S, Sewankambo N K, Serwadda D, Pudney J, Moody A, Harris J R, Griffin G E
机构信息
Bradford Royal Infirmary, UK.
出版信息
Gut. 1998 Sep;43(3):350-5. doi: 10.1136/gut.43.3.350.
AIMS
To compare jejunal mucosal morphometry in HIV infected patients resident in London and Uganda.
PATIENTS
Twenty HIV positive patients from London and 16 from Uganda were studied, and compared with HIV negative control subjects from both sites.
METHODS
Stools and biopsy specimens were examined for enteropathogens. Surface area to volume (S:V) ratio was estimated morphometrically, mean crypt length of jejunal biopsy specimens was measured, and HIV infected cells detected immunohistochemically were quantified.
RESULTS
Enteric pathogens were detected in none of the London patients, and in three Ugandan patients. S:V ratio was lower, and mean crypt length higher, in the specimens of London patients than in normal subjects, but there was no difference in S:V ratio or mean crypt length between Ugandan patients and controls. A negative correlation was present between S:V ratio and mean crypt length in all biopsy specimens analysed. HIV infected cells were detected only in lamina propria.
CONCLUSION
Infection of cells in the lamina propria of the jejunum with HIV stimulates crypt cell proliferation, and a fall in villous surface area. The mucosal response to HIV is masked by other pathogens in the African environment.
目的
比较伦敦和乌干达的HIV感染患者的空肠黏膜形态学。
患者
研究了20名来自伦敦的HIV阳性患者和16名来自乌干达的HIV阳性患者，并与来自这两个地点的HIV阴性对照受试者进行比较。
方法
对粪便和活检标本进行肠道病原体检查。通过形态计量学估计表面积与体积（S:V）比，测量空肠活检标本的平均隐窝长度，并对免疫组化检测到的HIV感染细胞进行定量。
结果
伦敦患者中未检测到肠道病原体，乌干达患者中有3例检测到。伦敦患者标本的S:V比低于正常受试者，平均隐窝长度高于正常受试者，但乌干达患者与对照之间的S:V比或平均隐窝长度无差异。在所有分析的活检标本中，S:V比与平均隐窝长度呈负相关。仅在固有层检测到HIV感染细胞。
结论
HIV感染空肠固有层细胞会刺激隐窝细胞增殖，并导致绒毛表面积减少。在非洲环境中，其他病原体掩盖了黏膜对HIV的反应。
Zotero 插件