氧化应激与抗氧化在动脉粥样硬化发病机制中的作用：对氧化型低密度脂蛋白假说的启示
Oxidants and antioxidants in the pathogenesis of atherosclerosis: implications for the oxidized low density lipoprotein hypothesis.
作者信息
Heinecke J W
机构信息
Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.
出版信息
Atherosclerosis. 1998 Nov;141(1):1-15. doi: 10.1016/s0021-9150(98)00173-7.
PMID:9863534
Abstract
The oxidation hypothesis proposes that low density lipoprotein must be oxidatively modified to trigger the pathological events of atherosclerosis. In this article, we evaluate recent studies addressing the pathways that promote low density lipoprotein oxidation in vivo and the impact of antioxidants on atherogenesis in animals, paying particular attention to the clinical implications of these studies for the oxidation hypothesis.
摘要
氧化假说提出，低密度脂蛋白必须经过氧化修饰才能引发动脉粥样硬化的病理过程。在本文中，我们评估了近期有关体内促进低密度脂蛋白氧化途径以及抗氧化剂对动物动脉粥样硬化形成影响的研究，特别关注这些研究对氧化假说的临床意义。
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