Matalliotakis I, Neonaki M, Giannakopoulou C, Goumenou A, Hassan E, Koumantakis E
Department of Obstetrics and Gynaecology, University Hospital, Iraklion, Crete, Greece.
Int J Fertil Womens Med. 1998 Sep-Oct;43(5):262-6.
The aim of the study was to establish if pregnancy belongs to pathological situations, if it changes SIL-2R, sCD4 and sCD8 levels, and to verify if these levels have a prognostic value in the evaluation of pregnancy.
Thirty pregnant women in the first trimester of pregnancy were studied. Ten of them had a normal evolution of pregnancy, ten had a threatened abortion with a bad outcome, and ten had an ectopic pregnancy. We determined SIL-2R, sCD4, and sCD8 levels in the serum and in the amniotic fluid in 10 pregnant women in their second trimester, and in 10 healthy women without pregnancy (control group).
We found that (a) 50% of the pregnant women in their first trimester had abnormal SIL-2R values, and 90% had abnormal sCD8 values; (b) 9/10 women with threatened abortion and bad outcome had abnormal SIL-2R values; (c) SIL-2R levels were significantly higher in the amniotic fluid than in the serum (P <.001).
Our results sustain the opinion that pregnancy must be included among those situations that increase SIL-2R, sCD4, and sCD8 levels. SIL-2R levels greater than 1,300 U/mL carried a bad prognosis in the evolution of pregnancy.
本研究旨在确定妊娠是否属于病理情况，是否会改变可溶性白细胞介素-2受体（SIL-2R）、可溶性CD4（sCD4）和可溶性CD8（sCD8）水平，并验证这些水平在妊娠评估中是否具有预后价值。
对30名妊娠早期妇女进行了研究。其中10名妊娠过程正常，10名有先兆流产且结局不良，10名有异位妊娠。我们测定了10名妊娠中期孕妇以及10名未孕健康妇女（对照组）血清和羊水中的SIL-2R、sCD4和sCD8水平。
我们发现：（a）50%的妊娠早期妇女SIL-2R值异常，90%的sCD8值异常；（b）9/10有先兆流产且结局不良的妇女SIL-2R值异常；（c）羊水中的SIL-2R水平显著高于血清（P<.001）。
我们的结果支持以下观点，即妊娠必须被纳入会增加SIL-2R、sCD4和sCD8水平的情况之中。SIL-2R水平大于1300 U/mL对妊娠进展的预后不良。
