Penney D, Anderson D, Dongas J
J Nutr. 1976 Sep;106(9):1235-40. doi: 10.1093/jn/106.9.1235.
Following weaning, rats from litter sizes of 15 to 20 were subjected to severe food restriction for 10 weeks, and compared to rats from litter size 5 fed ad libitum. Percent M (muscle type) lactate dehydrogenase, M and H (heart type) subunit activity and lactate dehydrogenase activity (per g wet weight) determined both electrophoretically and spectrophotometrically were all significantly lower in separated left and right ventricles of the malnourished rats. There were no differences in skeletal muscle lactate dehydrogenase activity. Following 5 weeks of ad libitum feeding, the previously malnourished rats showed large increases in body weight. Now only the right ventricle showed slight decreases in H subunit and lactate dehydrogenase activity; other measurements in the right ventricle and all in the left ventricle had returned to control levels. Skeletal muscle lactate dehydrogenase activity was not different from controls.
断奶后，将窝仔数为15至20只的大鼠进行10周的严格食物限制，并与自由采食的窝仔数为5只的大鼠进行比较。通过电泳和分光光度法测定的营养不良大鼠分离的左、右心室中M（肌肉型）乳酸脱氢酶百分比、M和H（心脏型）亚基活性以及乳酸脱氢酶活性（每克湿重）均显著降低。骨骼肌乳酸脱氢酶活性没有差异。自由采食5周后，先前营养不良的大鼠体重大幅增加。此时，只有右心室的H亚基和乳酸脱氢酶活性略有下降；右心室的其他测量值以及左心室的所有测量值均恢复到对照水平。骨骼肌乳酸脱氢酶活性与对照组无差异。
