De Galdeano A G, Boyano D, Cañavate L
Department of Cell Biology and Morphological Sciences, School of Medicine and Dentistry, University of the Basque Country, Leioa 48940, Vizcaya, Spain.
Oncol Rep. 1999 Jan-Feb;6(1):225-8.
We have previously demonstrated that in vitro treatment with interleukins (IL-2 and IL-6) enhances metastasis in B16 murine melanoma. IL-1 has been reported to be involved in the metastatic activity of human melanoma; so in the present study we have investigated if IL-1 could also modulate the behaviour of this experimental tumor. Data showed that low doses of IL-1 induced cell proliferation and several modifications in the expression of MHC antigens, fibronectin and laminin, however these changes did not lead to a higher metastatic efficiency. In addition it was shown that B16F10 cells express IL-1 mRNA. It can be concluded that IL-1 may be involved in the biology of B16F10 cells although its role in metastasis needs further investigation.
我们之前已经证明，用白细胞介素（IL-2和IL-6）进行体外处理可增强B16小鼠黑色素瘤的转移。据报道，IL-1参与人类黑色素瘤的转移活性；因此在本研究中，我们研究了IL-1是否也能调节这种实验性肿瘤的行为。数据显示，低剂量的IL-1诱导细胞增殖以及MHC抗原、纤连蛋白和层粘连蛋白表达的若干变化，然而这些变化并未导致更高的转移效率。此外还表明，B16F10细胞表达IL-1 mRNA。可以得出结论，IL-1可能参与B16F10细胞的生物学过程，尽管其在转移中的作用需要进一步研究。
