Wittine M F, Freeman J B
JPEN J Parenter Enteral Nutr. 1977;1(3):152-5. doi: 10.1177/014860717700100302.
Eleven patients, receiving all nutrition intravenously, were given varying doses of calcium (0-20 mg/kg/day) to determine an optimal level for calcium administration during postoperative parenteral nutrition. During each study period, nitrogen, phosphorus, vitamin, and caloric intakes were constant. Negative calcium balance resulted when less than 2 mg Ca++/kg body weight was given daily. During excessive urinary calcium losses, serum calcium concentration remained in the normal range. Increasing calcium intake to approximately 5 mg/kg/day (500 mg/day) yielded an apparent retention of calcium, as did higher doses. Serum calcium did not rise at this time. Urinary calcium excretion was directly proportional to calcium intake. The preliminary data suggest that a minimum dose of 5 mgCa++/kg/day is necessary to attain equilibrium between intake and urinary output. This value is higher than recent suggestions for calcium replacement during intravenous feeding.
11名接受全静脉营养的患者被给予不同剂量的钙（0 - 20毫克/千克/天），以确定术后肠外营养期间钙给药的最佳水平。在每个研究期间，氮、磷、维生素和热量摄入保持恒定。当每日给予的钙低于2毫克Ca++/千克体重时，会出现负钙平衡。在尿钙过度流失期间，血清钙浓度保持在正常范围内。将钙摄入量增加到约5毫克/千克/天（500毫克/天）时，钙出现明显潴留，更高剂量时也是如此。此时血清钙并未升高。尿钙排泄与钙摄入量成正比。初步数据表明，每天至少需要5毫克Ca++/千克的剂量才能使摄入和尿排出达到平衡。该值高于近期关于静脉喂养期间钙补充的建议。
