Sleckman B G, Mauch P M, Ambinder R F, Mann R, Pinkus G S, Kadin M E, Sherburne B, Perez-Atayde A, Thior I, Mueller N
Harvard Medical School, Boston, Massachusetts 02115, USA.
Cancer Epidemiol Biomarkers Prev. 1998 Dec;7(12):1117-21.
Risk factors suggestive of relatively late exposure to EBV have been consistently associated with Hodgkin's disease (HD) in younger adults. In addition, evidence of EBV infection has been found in the Reed-Sternberg cells themselves in about one-third to one-half of all HD cases. However, no study yet published has correlated these childhood social environment risk factors with the presence of EBV in Hodgkin's tumor cells. We examined whether EBV-positive HD occurs in those patients whose childhood environment would predispose them to relatively late exposure to EBV. The study population consisted of 102 cases of mixed cellularity (MC; n = 25) or nodular sclerosing (n = 77) HD. Samples that tested positive for either EBV-encoded RNA or latent membrane protein or both were considered EBV-positive. Of the 102 cases, 83 completed a questionnaire regarding childhood social environment. The association with EBV-positivity was estimated by the odds ratio (OR) with 95% confidence intervals (CI). Twenty-two percent of the cases were EBV-positive. These cases were more likely to be MC (OR, 6.2; CI, 2.3-16.3) and male (OR, 3.4; CI, 1.3-9.0). History of infectious mononucleosis (IM) was not predictive of EBV-positivity, with only 3 of 14 such patients being EBV-positive (P = 0.82). Contrary to our hypothesis, no association between EBV and childhood environment risk factors was identified. The association of EBV with MC histology and male gender agrees with previous reports. The most intriguing finding was the dissociation between IM history and EBV-positivity, in that almost all of the cases with a history of IM were EBV-negative.
提示相对较晚感染EB病毒的风险因素一直与年轻成年人的霍奇金淋巴瘤（HD）相关。此外，在所有HD病例中，约三分之一至二分之一的里德-斯腾伯格细胞本身发现了EB病毒感染的证据。然而，尚未发表的研究将这些儿童期社会环境风险因素与霍奇金肿瘤细胞中EB病毒的存在联系起来。我们研究了EBV阳性的HD是否发生在那些童年环境使其易发生相对较晚EBV暴露的患者中。研究人群包括102例混合细胞型（MC；n = 25）或结节硬化型（n = 77）HD。对EB病毒编码RNA或潜伏膜蛋白或两者检测呈阳性的样本被视为EBV阳性。在这102例病例中，83例完成了关于童年社会环境的问卷调查。通过优势比（OR）及95%置信区间（CI）评估与EBV阳性的相关性。22%的病例为EBV阳性。这些病例更可能是MC型（OR，6.2；CI，2.3 - 16.3）且为男性（OR，3.4；CI，1.3 - 9.0）。传染性单核细胞增多症（IM）病史不能预测EBV阳性，14例有IM病史的患者中只有3例为EBV阳性（P = 0.82）。与我们的假设相反，未发现EBV与儿童期环境风险因素之间存在关联。EBV与MC组织学类型及男性性别的关联与先前报道一致。最引人关注的发现是IM病史与EBV阳性之间的脱节，即几乎所有有IM病史的病例均为EBV阴性。
