Ordóñez N G, Mackay B
University of Texas, MD Anderson Cancer Center, Houston 77030, USA.
Hum Pathol. 1998 Dec;29(12):1403-11. doi: 10.1016/s0046-8177(98)90008-9.
The electron microscope reveals much more information on tumor cell structure than can be obtained with the light microscope, and some of the data are useful in diagnostic studies. In this review, major contributions of electron microscopy in the main tumor categories are discussed. To select between immunocytochemistry and electron microscopy, the probable contributions of each in the context of the particular case must be assessed. Usually, electron microscopy will only be requested after a battery of immunostaining procedures has been performed and found to be insufficient, but there are occasions when ulstrastructural study is logically the first choice after routine light microscopy. It is worth taking tissue for possible electron microscopy from any tumor that is known or anticipated to be a diagnostic problem.
电子显微镜所揭示的肿瘤细胞结构信息比光学显微镜所能获得的要多得多，其中一些数据在诊断研究中很有用。在这篇综述中，将讨论电子显微镜在主要肿瘤类别中的主要贡献。要在免疫细胞化学和电子显微镜之间做出选择，必须评估每种方法在特定病例中的可能贡献。通常，只有在一系列免疫染色程序已经进行且发现不足之后才会要求进行电子显微镜检查，但在某些情况下，超微结构研究在常规光学显微镜检查之后从逻辑上讲是首选。对于任何已知或预期会成为诊断难题的肿瘤，都值得取组织进行可能的电子显微镜检查。
