Ghoshal D, Sinha S, Sinha A, Bhattacharyya P
Department of Chemistry, Bose Institute 93/1, Calcutta, India.
Neurosci Lett. 1998 Nov 27;257(2):89-92. doi: 10.1016/s0304-3940(98)00808-8.
Kainate lesion of the vestibulo cerebellum induces sympathetic hyperactivity, but the mechanism of immunosuppression observed as a result is not yet clarified. Here we report that vestibulo cerebellum lesioned (VCL) rats have depressed secretion of haematopoietic cytokines (bioimmunomodulator or BIM, a 12.7 kD peptide and thymosin FrV) in tissue cultures of bone marrow and thymus, respectively, compared with controls (P < 0.01). Peripheral blood leukocyte concentration, neutrophil myeloperoxydase response, T-SRBC rosette and antibody titre to sheep red blood cells (SRBC) are also significantly less, compared with control (P < 0.01). Injection of BIM (concentration 0.01 microg/g body weight) in VCL rats corrected the immunodeficiency. Partial restoration of immune competence is observed after injection of thymosin FrV (0.01 microg/g body weight) or after prolonged vestibular stimulation (18 rpm for 15 min/day for 21 days). The results indicate that the vestibular nodule (VN) through autonomic nerves (AN) can modulate the immune function of rats by regulating the secretion of cytokines from bone marrow and thymus.
前庭小脑的红藻氨酸损伤会诱发交感神经功能亢进，但由此观察到的免疫抑制机制尚未阐明。在此我们报告，与对照组相比，前庭小脑损伤（VCL）大鼠在骨髓和胸腺的组织培养中分别出现造血细胞因子（生物免疫调节剂或BIM，一种12.7 kD的肽和胸腺素FrV）分泌减少（P < 0.01）。与对照组相比，外周血白细胞浓度、中性粒细胞髓过氧化物酶反应、T-SRBC玫瑰花结以及对绵羊红细胞（SRBC）的抗体滴度也显著降低（P < 0.01）。给VCL大鼠注射BIM（浓度0.01微克/克体重）可纠正免疫缺陷。注射胸腺素FrV（0.01微克/克体重）或经过长时间前庭刺激（18转/分钟，每天15分钟，持续21天）后，可观察到免疫能力部分恢复。结果表明，前庭小结（VN）通过自主神经（AN）可通过调节骨髓和胸腺细胞因子的分泌来调节大鼠的免疫功能。
