Man'kovs'ka I M, Seredenko M M, Vavilova H L, Kharlamova O M, Bystriukov V O
A. A. Bogomolets Institute of Physiology, National Academy of Sciences of Ukraine, Kiev.
Fiziol Zh (1994). 1998;44(5-6):65-72.
It was found that preliminary treatment by amino acid taurine protected rats from lipid peroxidation intensification (expressed in terms of malondialdehyde and conjugated dienes contents) in the liver, brain and heart under acute severe normobaric hypoxic hypoxia. The mechanisms of the antioxidant action of taurine are connected to the prevention of lactate accumulation in tissues and cell membrane structure disorders (expressed in a decrease of membrane Na+, K(+)-ATPase activity). It was also shown that taurine reduced significantly a decrease of glutathione antioxidant system activity protecting tissues against reduced glutathione pool depletion and preventing a decrease of glutathione reductase and glutathione peroxidase activities in acute severe hypoxia.
结果发现，在急性重度常压缺氧条件下，用氨基酸牛磺酸进行预处理可保护大鼠肝脏、大脑和心脏中的脂质过氧化加剧（以丙二醛和共轭二烯含量表示）。牛磺酸抗氧化作用的机制与防止组织中乳酸积累和细胞膜结构紊乱（表现为膜Na+、K(+)-ATP酶活性降低）有关。研究还表明，在急性重度缺氧时，牛磺酸可显著减少谷胱甘肽抗氧化系统活性的降低，保护组织免受还原型谷胱甘肽池耗竭的影响，并防止谷胱甘肽还原酶和谷胱甘肽过氧化物酶活性降低。
