Toyota K
Second Department of Surgery, Hiroshima University School of Medicine, Japan.
J Smooth Muscle Res. 1998 Feb;34(1):13-22. doi: 10.1540/jsmr.34.13.
Recently, gastrointestinal motility research and various studies to measure motility have been conducted. However, it is not easy to measure the pyloric sphincter motility, especially its open and closed motility. There are few reports on the opening and closed motility of the pyloric ring. In this study, I examined the pyloric motility with strain gauge force transducers (SGTs). SGTs were implanted onto the antrum, pyloric ring and duodenum of a dog. In order to clarify the relationship between the opening and closed motility of the pylorus and SGTs recordings, the pyloric ring was observed with a gastrofiberscope while measurements were taken using the SGTs in anesthetized dogs. In addition, the pyloric ring was extended mechanically with a balloon and measurement were taken using the SGTs. In conscious dogs, the natural gastropyloroduodenal motility was recorded. Then, cisapride, erythromycin, and Leu13-motilin were administered in the interdigestive state and the motility was recorded. The pyloric opening and closed motility could be monitored using SGTs. The pyloric ring opened when the pyloric motility recorded using the SGTs showed a negative deflection. In addition, in phase III, when intense contraction of the antrum was observed, relaxation and opening of the pyloric ring could be observed. Erythromycin and Leu13-motilin induced phase III-like motility and relaxation of the pyloric ring. However, in cisapride-induced motility, relaxation of the pyloric ring was not observed. The pyloric ring opening and closed motility can be monitored using SGTs and this method is effective for the evaluation of the pyloric function.
最近，已经开展了胃肠动力研究以及各种测量动力的研究。然而，测量幽门括约肌的动力并非易事，尤其是其开放和关闭动力。关于幽门环开放和关闭动力的报道很少。在本研究中，我使用应变片式力传感器（SGTs）检查了幽门动力。将SGTs植入犬的胃窦、幽门环和十二指肠。为了阐明幽门开放和关闭动力与SGTs记录之间的关系，在麻醉犬中使用SGTs进行测量时，用胃纤维镜观察幽门环。此外，用气囊对幽门环进行机械扩张，并使用SGTs进行测量。在清醒犬中记录自然的胃幽门十二指肠动力。然后，在消化间期给予西沙必利、红霉素和亮氨酸-13-胃动素，并记录动力。使用SGTs可以监测幽门的开放和关闭动力。当用SGTs记录的幽门动力显示负向偏转时，幽门环开放。此外，在Ⅲ期，当观察到胃窦强烈收缩时，可以观察到幽门环的松弛和开放。红霉素和亮氨酸-13-胃动素诱导Ⅲ期样动力和幽门环的松弛。然而，在西沙必利诱导的动力中，未观察到幽门环的松弛。使用SGTs可以监测幽门环的开放和关闭动力，并且该方法对于评估幽门功能是有效的。
