Keinke O, Schemann M, Ehrlein H J
Q J Exp Physiol. 1984 Oct;69(4):781-95. doi: 10.1113/expphysiol.1984.sp002868.
The aim of this study was to determine the mechanisms controlling gastric emptying of viscous meals. In four conscious dogs the antral, pyloric and duodenal activities were recorded with strain-gauge transducers and induction coils during gastric evacuation of an inert cellulose meal and of four nutrient meals containing mannitol, casein, glucose or oleic acid. Gastric emptying and the internal pyloric and duodenal diameters were measured from radiographs. The nutrients delayed gastric emptying and diminished to a various extent the antral and duodenal motility as well as the pyloric opening. The motility gradient between antral and duodenal activity showed no relationship to the emptying delay. The duodenal lumen was reduced and the propulsive contractions of the duodenum decreased while the segmental activity increased. The findings suggest that gastric emptying is controlled by (1) the depth of the antral waves, (2) the pyloric opening, (3) the receptive relaxation of the duodenum and (4) the type of the duodenal contractions. By contrast the sequence of the terminal antral contraction and the pyloric closure, as well as the co-ordination between pyloric and duodenal contractions, played no important role in regulating gastric emptying.
本研究的目的是确定控制粘性食物胃排空的机制。在四只清醒的狗身上，用应变片传感器和感应线圈记录了在惰性纤维素食物以及含有甘露醇、酪蛋白、葡萄糖或油酸的四种营养食物胃排空期间的胃窦、幽门和十二指肠活动。通过X光片测量胃排空以及幽门和十二指肠的内径。营养物质延迟了胃排空，并在不同程度上减弱了胃窦和十二指肠的运动以及幽门开放。胃窦和十二指肠活动之间的运动梯度与排空延迟无关。十二指肠管腔缩小，十二指肠的推进性收缩减少，而节段性活动增加。研究结果表明，胃排空受以下因素控制：（1）胃窦波的深度，（2）幽门开放，（3）十二指肠的容受性舒张，以及（4）十二指肠收缩的类型。相比之下，胃窦终末收缩和幽门关闭的顺序，以及幽门和十二指肠收缩之间的协调性，在调节胃排空方面没有起到重要作用。
