Nizet A, Robin M, Merchie G
Pflugers Arch. 1976 Jun 29;364(1):59-64. doi: 10.1007/BF01062912.
The influence of an intravenous infusion of saline on the absorption of water and sodium by the jejunum has been investigated in dogs previously submitted to sodium-rich or poor diets. While the net intestinal transport was reduced in sodium-loaded animals, no response was observed in the sodium-deprived dogs, despite identical changes in arterial pressure, intravascular volume and blood dilution indexes. The intestinal response of sodium-deprived dogs became positive after transplanting to their neck vessels the kidneys removed from sodium-loaded animals, thus demonstrating that the presence in the blood of a humoral message of renal origin is required to permit the inhibition of net transport. The difference of the responses depended on the variations of the mucosa-to-serosa unidirectional flux. The net potassium transport did not change significantly. The experimental conditions made unlikely an interference of mineralocorticosteroids, angiotensin or antidiuretic hormone. The present results suggest that the kidney might modulate sodium transport in the jejunum, and perhaps elsewhere in the body, by the way of an additional endocrine function.
在先前摄入高钠或低钠饮食的犬类中，研究了静脉输注生理盐水对空肠水和钠吸收的影响。虽然钠负荷动物的肠道净转运减少，但在缺钠犬中未观察到反应，尽管动脉压、血管内容量和血液稀释指数发生了相同变化。将从钠负荷动物身上摘除的肾脏移植到缺钠犬的颈部血管后，缺钠犬的肠道反应变为阳性，从而表明血液中存在肾源性体液信息是抑制净转运所必需的。反应的差异取决于黏膜到浆膜单向通量的变化。净钾转运没有显著变化。实验条件不太可能受到盐皮质激素、血管紧张素或抗利尿激素的干扰。目前的结果表明，肾脏可能通过额外的内分泌功能来调节空肠以及可能身体其他部位的钠转运。
